Clinical outcomes of a digital musculoskeletal women's pelvic health program: an observational, longitudinal study with comparison group.

Background: Chronic pelvic pain is a common yet undertreated condition that significantly impacts quality of life for women worldwide. Digital exercise therapy designed to target pelvic pain can improve symptomology while reducing time and cost-related barriers to in-person clinical care.

Methods: This longitudinal, observational study of a digital women's pelvic health program examined pelvic pain, anxiety, and depression at 4 and 12 weeks in female adults experiencing chronic pelvic pain.

Bioleaching of lithium from jadarite, spodumene, and lepidolite using .

Lithium (Li) is becoming increasingly important due to its use in clean technologies that are required for the transition to net zero. Although acidophilic bioleaching has been used to recover metals from a wide range of deposits, its potential to recover Li has not yet been fully explored. In this study, we used a model Fe(II)- and S-oxidising bacterium, (At.

The Europa Imaging System (EIS) Investigation.

The Europa Imaging System (EIS) consists of a Narrow-Angle Camera (NAC) and a Wide-Angle Camera (WAC) that are designed to work together to address high-priority science objectives regarding Europa's geology, composition, and the nature of its ice shell. EIS accommodates variable geometry and illumination during rapid, low-altitude flybys with both framing and pushbroom imaging capability using rapid-readout, 8-megapixel (4k × 2k) detectors. Color observations are acquired using pushbroom imaging with up to six broadband filters.

Pharmacokinetics, Pharmacodynamics, Bioavailability, and Immunogenicity of Obexelimab Following Subcutaneous Administration in Healthy Japanese and Non-Japanese Volunteers.

Introduction: Obexelimab is an investigational, bifunctional, non-depleting, humanized monoclonal antibody that binds CD19 and FcγRIIb to inhibit B cells, plasmablasts, and CD19-expressing plasma cells. In clinical trials, intravenous (IV) administration of obexelimab has been well-tolerated, and demonstrated clinical activity in patients with rheumatoid arthritis, systemic lupus erythematosus, and immunoglobulin G4-related disease. This study was performed to evaluate the pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of obexelimab following subcutaneous (SC) administration, and compare PK/PD profiles between healthy Japanese and non-Japanese volunteers.

Gastrointestinal Device-Mediated Delivery of mRNA-Lipid Nanoparticles Achieves Distinct Expression and Biodistribution in Mice and Pigs.

Recent investigations into autonomous ingestible microjet devices have demonstrated the feasibility of delivering many drug modalities directly into the gastrointestinal (GI) wall via the oral route. However, the expression and biodistribution of mRNA after such injections remain unexplored. mRNA-lipid nanoparticles (mRNA-LNPs) are promising therapeutics for treating or vaccinating against many diseases and pathogens.

Cephalopod-inspired jetting devices for gastrointestinal drug delivery.

Needle-based injections currently enable the administration of a wide range of biomacromolecule therapies across the body, including the gastrointestinal tract, through recent developments in ingestible robotic devices. However, needles generally require training, sharps management and disposal, and pose challenges for autonomous ingestible systems. Here, inspired by the jetting systems of cephalopods, we have developed and evaluated microjet delivery systems that can deliver jets in axial and radial directions into tissue, making them suitable for tubular and globular segments of the gastrointestinal tract.

Connectivity of toxigenic Pseudo-nitzschia species assemblages between the Northeast U.S. continental shelf and an adjacent estuary.

Pseudo-nitzschia harmful algal blooms have recently caused elevated domoic acid in coastal environments of the Northeast United States. In 2017, the toxigenic species P. australis was observed in Narragansett Bay, Rhode Island, a temperate estuarine ecosystem, for the first time since 2009 when DNA monitoring for Pseudo-nitzschia species began.

Who cares about lab rodents?

Humanities and social sciences help advance "cultures of care" around laboratory animal science and welfare.

Lessons for the Future of NAMs from History, Philosophy and Social Studies of Science.

This paper explores what we can learn from the humanities and social sciences about how standards operate in and around science, in order to understand more about how 'the gold standard' can be shifted away from the use of animals in research and testing, and toward New Approach Methodologies (NAMs). These fields allow us to consider potential futures of NAMs as alternatives, replacements, or complements to animal use in testing and research. As we demonstrate, the questions that we pose and how they are framed are as important as the answers that result.

Data linkage studies of primary care utilisation after release from prison: a scoping review.

Background: Primary care plays a central role in most, if not all, health care systems including the care of vulnerable populations such as people who have been incarcerated. Studies linking incarceration records to health care data can improve understanding about health care access following release from prison. This review maps evidence from data-linkage studies about primary care use after prison release.

Choline-deficient, high-fat diet-induced MASH in Göttingen Minipigs: characterization and effects of a chow reversal period.

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) is increasing, and translational animal models are needed to develop novel treatments for this disease. The physiology and metabolism of pigs have a relatively high resemblance to humans, and the present study aimed to characterize choline-deficient and high-fat diet (CDAHFD)-fed Göttingen Minipigs as a novel animal model of MASLD/MASH. Göttingen Minipigs were fed CDAHFD for up to 5 mo, and the phenotype was investigated by the analysis of plasma parameters and repeated collection of liver biopsies.

Electrophilic As-functionalisation of σ-arsolido complexes.

The σ-arsolido complex [Mo(AsCMe)(CO)(η-CH)] is alkylated at arsenic by MeOTf to afford the pentamethylarsole complex [Mo(MeAsCMe)(CO)(η-CH)](OTf) while iodomethane affords a mixture of [MeAsCMe]I, [MoMe(CO)(η-CH)], [MoI(CO)(η-CH)] and the arsole complexes - and -[MoI(MeAsCMe)(CO)(η-CH)] and -[Mo{C(O)Me}(MeAsCMe)(CO)(η-CH)], The arsole ligand in [Mo(MeAsCMe)(CO)(η-CH)](OTf) is readily liberated by NaI in acetone to afford free MeAsCMe and [MoI(CO)(η-CH)]. In a similar manner, the reaction of [Mo(AsCPh)(CO)(η-CH)] with MeI affords MeAsCPh and [MoI(CO)(η-CH)], while [Mo{AsC(SiMe)-2-Me-3,4}(CO)(η-CH)] with MeOTf affords [Mo{MeAsC(SiMe)-2-Me-3,4}(CO)(η-CH)](OTf). The reaction of [Mo(AsCMe)(CO)(η-CH)] with activated alkynes (RCCR: R = CF, COMe) does not proceed [4 + 2] -addition but rather electrophilic attack at arsenic followed by metallacyclisation with incorporation of a carbonyl ligand in the spirocyclic complexes [Mo{As(CMe)CRCRCO}(CO)(η-CH)].

σ-Arsolido complexes.

The σ-stannyl complexes [M(SnBu)(CO)(η-CH)] ( = 3, M = Mo, W; = 2, M = Fe) serve as mild reagents for the installation of σ-arsolyl ligands in transmetallation reactions with As-chloro-arsoles ClAsCR (R = Me, Ph) to afford [M(σ-AsCR)(CO)(η-CH)]. The reaction of [Cr(SnBu)(CO)(η-CH)] with ClAsCPh most likely proceeds in a similar manner but is immediately followed by rapid formation of (AsCPh) and [Cr(CO)(η-CH)]. The reaction of [Mo(SnBu)(CO)(η-CH)] with ClAsC(SiMe)-2,5-Me-3,4 is accompanied by monodesilylation to afford [Mo{σ-AsC(SiMe)-2-Me-3,4}(CO)(η-CH)].

Spatial and Temporal Resolution of Cyanobacterial Bloom Chemistry Reveals an Open-Ocean as a Talented Producer of Specialized Metabolites.

While the ecological role that sp. play in nitrogen fixation has been widely studied, little information is available on potential specialized metabolites that are associated with blooms and standing stock colonies. While a collection of biological material from a bloom event from North Padre Island, Texas, in 2014 indicated that this species was a prolific producer of chlorinated specialized metabolites, additional spatial and temporal resolution was needed.

What the pediatric nurse needs to know about the Impella cardiac assist device.

Cardiogenic shock in children still carries a high mortality risk despite advances in medical therapy. The use of temporary mechanical circulatory supports is an accepted strategy to bridge patients with acute heart failure to recovery, decision, transplantation or destination therapy. These devices are however limited in children and extracorporeal membrane oxygenation (ECMO) remains the most commonly used device.

Human growth factor-mediated signalling through lipid rafts regulates stem cell proliferation, development and survival of .

Although the mechanisms by which schistosomes grow and develop in humans are poorly defined, their unique outer tegument layer, which interfaces with host blood, is considered vital to homeostasis of the parasite. Here, we investigated the importance of tegument lipid rafts to the biology of in the context of host-parasite interactions. We demonstrate the temporal clustering of lipid rafts in response to human epidermal growth factor (EGF) during early somule development, concomitant with the localization of anteriorly orientated EGF receptors (EGFRs) and insulin receptors, mapped using fluorescent EGF/insulin ligand.

Poly(imidazolyliden-yl)borato Complexes of Tungsten: Mapping Steric vs. Electronic Features of Coordinating Ligands.

A convenient synthesis of [HB(HImMe)](PF) (ImMe = -methylimidazolyl) is decribed. This salt serves in situ as a precursor to the tris(imidazolylidenyl)borate Li[HB(ImMe)] pro-ligand upon deprotonation with BuLi. Reaction with [W(≡CCHMe-4)(CO)(pic)(Br)] (pic = 4-picoline) affords the carbyne complex [W(≡CCHMe-4)(CO){HB(ImMe)}].

Schistosoma mansoni excretory-secretory products induce protein kinase signalling, hyperkinesia, and stem cell proliferation in the opposite sex.

Adult male and female schistosomes in copula dwell within human blood vessels and lay eggs that cause the major Neglected Tropical Disease human schistosomiasis. How males and females communicate to each other is poorly understood; however, male-female physical interaction is known to be important. Here, we investigate whether excretory-secretory products (ESPs), released into the external milieu by mature Schistosoma mansoni, might induce responses in the opposite sex.

Free and coordinated biarsolyls.

A trace side product from the reaction of [Mo(AsCMe)(CO)(η-CH)] with [Mn(THF)(CO)(η-CHMe)] was identified as the biarsolyl complex [Mn{μ-(AsCMe)}(CO)(CHMe)] on the basis of a strategic synthesis from [Mn(THF)(CO)(η-CHMe)] and the pre-formed and structurally characterised biarsolyl (AsCMe). Crystallographic and computational data for this first example of a biarsolyl complex and free biarsolyls are discussed in the context of those for free biarsolyls.

Cardiovascular remodelling in response to exercise training in patients after the Fontan procedure: a pilot study.

Background: The cardiovascular adaptations associated with structured exercise training in Fontan patients remain unknown. We hypothesised that short-term training causes cardiac remodelling and parallel improvement in maximal exercise capacity (VO2 max) in these patients.

Methods And Results: Five patients, median age 19.

Exploring the Interior of Europa with the Europa Clipper.

The Galileo mission to Jupiter revealed that Europa is an ocean world. The Galileo magnetometer experiment in particular provided strong evidence for a salty subsurface ocean beneath the ice shell, likely in contact with the rocky core. Within the ice shell and ocean, a number of tectonic and geodynamic processes may operate today or have operated at some point in the past, including solid ice convection, diapirism, subsumption, and interstitial lake formation.

Use of poxvirus display to select antibodies specific for complex membrane antigens.

Antibody discovery against complex antigens is limited by the availability of a reproducible pure source of concentrated properly folded antigen. We have developed a technology to enable direct incorporation of membrane proteins such as GPCRs and into the membrane of poxvirus. The protein of interest is correctly folded and expressed in the cell-derived viral membrane and does not require any detergents or refolding before downstream use.

Record linkage studies of primary care utilisation after release from prison: A scoping review protocol.

Introduction: There is a need to improve the implementation and provision of continuity of care between prison and community in order that people who have been in prison and have a history of low engagement with services or who are vulnerable receive appropriate and timely health care and treatment. Observational studies using record linkage have investigated continuity of care after release from prison but this type of research evidence has not been synthesised.

Objective: This paper presents a protocol designed to review record linkage studies about primary care utilisation after prison release in order to inform future research and guide service organisation and delivery towards people who are at-risk following release from prison.