Efficacy and Safety of Ileal Bile Acid Transport Inhibitors in Inherited Cholestatic Liver Disorders: A Meta-analysis of Randomized Controlled Trials.

Background: Inherited cholestatic liver disorders such as progressive familial intrahepatic cholestasis (PFIC) and Alagille syndrome result in significant pruritus and increased serum bile acids, necessitating liver transplantation. This study aims to evaluate the efficacy and safety of Ileal bile acid transport inhibitors (IBATIs) in children with PFIC and Alagille syndrome.

Methods: We conducted a comprehensive search across the databases to identify relevant randomized controlled trials (RCTs), and Covidence was used to screen eligible articles.

Spatiotemporal variation in population size and relative abundance of Kalij pheasant (Lophura leucomelanos) in scrub forest.

Most species of pheasants (Galliformes: Phasianidae) occur in Asia. In Pakistan, pheasants occur from 245-3050 m in altitude, and one of these, the Kalij pheasant (Lophura leucomelanos) is a large-bodied, brightly-colored habitat quality indicator species. The present study was designed to determine spatiotemporal variation, population size, and the relative abundance of Kalij pheasants in Haripur, Pakistan.

Efficacy and Safety of Intravenous Immunoglobulin (IVIg) in Acute Viral Myocarditis in Children: A Systematic Review of Randomized Controlled Trials.

Context: Acute myocarditis is a rare but potentially life-threatening condition in infants and children. While immunosuppressive agents have shown limited effectiveness, intravenous immunoglobulin (IVIg) holds promise as a treatment option.

Objective: To study the efficacy and safety of intravenous immunoglobulin (IVIg) in treating acute viral myocarditis in children.

Systematic review of the association between thyroid disorders and hyperprolactinemia.

Introduction: Thyroid disease (TD), particularly hypothyroidism, is an important etiology of hyperprolactinemia (HPRL). We conducted a systematic review of the clinical characteristics, management, and outcomes of adults (> 18 years) with this clinical association.

Materials And Methods: We searched PUBMED, SCOPUS, and EMBASE to find eligible articles published in English from any date till 15th December 2022.

Cerebral Venous Sinus Thrombosis Linked to Dietary Supplement Use in a Bodybuilder: A Case Report.

Many dietary supplements commonly used by bodybuilders and athletes carry thrombogenic risks, potentially leading to life-threatening conditions like arterial and venous thrombosis by either elevating testosterone levels or directly interfering with homeostasis. Increased awareness and further research are crucial for consumer safety and supplement regulation.

Habitat suitability modeling and conservation status of Salvadora oleoides and Tamarix aphylla in tropical thorn forest.

The habitat suitability of Salvadora oleoides and Tamarix aphylla can be one of the most significant steps towards conserving these tree species. Habitat loss presents a critical threat to the existence of S. oleoides and T.

Late onset epilepsy findings in a developmental country, a report of first results.

Introduction: Older patients with Late onset epilepsy (LOE) provide a special set of difficulties for both the treating doctors and the patients.

Objectives: To address the characteristics and treatment outcomes of LOE in a cohort of Egyptian population at a tertiary center and to assess factors affecting seizure freedom in this age group.

Methods: From December 1, 1995, to November 30, 2020, we analysed all patients with newly diagnosed epilepsy above the age of 50 at Cairo University's neurology department.

Clinical utility of plasma microbial cell-free DNA sequencing in determining microbiologic etiology of infectious syndromes in solid organ transplant recipients.

Background: Metagenomic next-generation sequencing (mNGS) is increasingly being used for microbial detection in various infectious syndromes. However, data regarding the use of mNGS in solid organ transplant recipients (SOTR) are lacking.

Objectives: To describe and analyze real-world clinical impact of mNGS using plasma microbial cell-free DNA (mcfDNA) in SOTR.

Silver nanoparticles loaded with pomegranate peel extract and hyaluronic acid mediate recovery of cutaneous wounds infected with .

Smart innovative nanocomposites based on active ingredients and metallic nanoparticles with effective wound healing and antifungal properties are efficient in overcoming the limitations of traditional therapeutic products. Open wounds provide an ideal niche for colonization by () which poses substantial global health issues owing to delayed wound healing and disordered healing mechanisms. Therefore, proficient innovative therapies that control infection and promote wound healing are of imperative importance for the management of wounds and prevention of infection and possible complications.

The Influence of Timing of Surgery on Postoperative Length of Hospital Stay in Closed Ankle Fractures.

Background Ankle fractures are prevalent lower limb injuries that often necessitate surgical intervention to restore joint stability and functionality. Delays in surgical management can extend hospital stays and elevate the risk of complications. This study aims to evaluate the effect of surgical timing on the postoperative length of hospital stay in patients with closed ankle fractures managed through open reduction and internal fixation (ORIF).

Efficacy of Local Intralesional Steroid Injection for Pain Relief in De Quervain's Tenosynovitis.

Introduction: Conservative treatment options, such as rest, massage, cold and heat packs, wrist splints, braces, physical therapy, thumb spica casts, and local steroid injections, have been used with mixed results to treat De Quervain's tenosynovitis. Surgical treatment, like releasing the first dorsal wrist compartment, is the last resort for resistant cases of De Quervain's tenosynovitis, exhibiting an efficacy of 91%. However, complications and increased expenses have limited the use of surgical interventions.

Global Epidemiology and Characteristics of Metabolic-associated Steatotic Liver Disease in Type 1 Diabetes Mellitus: An Updated Systematic Review and Meta-analysis.

Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is often overlooked in patients with type 1 diabetes mellitus (T1DM). Our study aims to provide a comprehensive overview of the burden of MASLD in T1DM by assessing the prevalence of MASLD and its advanced forms in individuals with T1DM.

Methods: We systematically searched PubMed and Embase databases (from inception to May 5, 2024) for original articles on the prevalence or characteristics of MASLD (as detected by blood biomarkers/scores, imaging techniques, or liver biopsy) in adults with T1DM.

Efficacy and Safety of LigaSure in Breast Surgery With Axillary Lymph Node Dissection in Patients With Breast Cancer: A Systematic Review and Meta-Analysis.

Background: Conventional axillary lymph node dissection (ALND) is associated with significant post-operative morbidity in patients undergoing breast surgery due to increased lymphatic leakage. LigaSure, an electrothermal bipolar vessel sealing system, provides better closure of the leakage. This study aims to compare the efficacy and safety of LigaSure against conventional techniques in patients with breast cancer underwent ALND and breast surgery.

Efficacy of Platelet-Rich Plasma (PRP) in Treating Plantar Fasciitis.

Background: Platelet-rich plasma (PRP) is an autologous blood derivative with an enhanced platelet concentration and can enhance the tissue-healing process naturally. Plasma with a higher concentration of platelets on activation leads to the release of various growth factors that in turn augment tissue repair and jump-start the healing process. The aim of this study was to determine the efficacy of PRP in reducing pain and improving functional outcomes in patients with plantar fasciitis who had failed to respond to conservative treatment.

Fabrication of an In Situ pH-Responsive Raloxifene-Loaded Invasome Hydrogel for Breast Cancer Management: In Vitro and In Vivo Evaluation.

Background/objectives: Raloxifene (RLF) is a therapeutic option for invasive breast cancer because it blocks estrogen receptors selectively. Low solubility, limited targeting, first-pass action, and poor absorption are some of the challenges that make RLF in oral form less effective. This study aimed to create an intra-tumoral in situ pH-responsive formulation of RLF-invasome (IPHRLI) for breast cancer treatment, with the goals of sustaining RLF release, minimizing adverse effects, and enhancing solubility, bioavailability, targeting, and effectiveness.

Transformation study and characterization of Cu-BTC MOF-derived nanoporous copper oxide.

This study provides a systematic and comprehensive investigation of the transformation process of copper-based metal-organic frameworks (Cu-BTC MOFs) into nanoporous copper oxides (P-CuO) through controlled calcination. While calcination is a well-established method for producing MOF-derived oxides, previous studies have primarily focused on their applications. Most of them often lack detailed exploration of the transformation process and decomposition mechanisms though it is crucial for achieving tunability in MOF-derived structures.

infection and hepatocellular carcinoma: a comorbidity study.

Background: The implication of human () infection in concomitance with other risk factors such as hepatitis C virus (HCV) and hepatitis B virus (HBV) in the development of hepatocellular carcinoma (HCC) is still under controversy. This work aimed. to evaluate the role of infection in association with hepatitis B virus (HBV), hepatitis C virus (HCV) and other risk factors in the development and/or progress of HCC.

Gamma irradiation green synthesis of (polyacrylamide/chitosan/silver nanoparticles) hydrogel nanocomposites and their using as antifungal against Candida albicans and anti-cancer modulator.

Silver nanoparticles-loaded hydrogel nanocomposites are exploited for medicinal and pharmaceutical applications. Hydrogel nanocomposites were prepared from acrylamide (Am), chitosan (CS) and AgNO utilizing gamma rays. Diverse variables were applied in preparation of silver nanoparticles-laoded hydrogel nanocomposites of (PAm/CS)-AgNPs such as influence of radiation dose and influnece of CS concentration.

Comparison of risk factors and mortality in veterans with HIV and those without HIV suffering first major acute cardiovascular events.

Background: Previous studies have demonstrated that people with HIV have an increased atherosclerotic plaque vulnerability, making them more susceptible to severe cardiovascular complications. This study aimed to examine the clinical characteristics of people with HIV in comparison to people without HIV admitted to Veterans Health Administration (VHA) with their first major acute cardiovascular events (MACE) and compare their total mortality.

Methods: We used national VHA data to extract data of those admitted to VHA hospitals with MACE defined as acute myocardial infarction (AMI), acute cerebrovascular accident (CVA) or cardiac arrest during the fiscal years 2003-2021.