Publications by authors named "KELEMEN A"

Background/objectives: Films in the mouth offer a promising alternative drug delivery system for oral administration, with several advantages over traditional oral formulations. Furthermore, their non-invasive nature and easy administration make them conducive to increasing patient compliance. The use of active agents in these films can further improve their drug delivery properties, making them an even more useful drug delivery system.

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Introduction: Intestinal ischemia/reperfusion (I/R) injury is associated with high mortality and there is an unmet need for novel therapies. The intestinal expression of cyclooxygenase-2 (COX-2) increases rapidly after mesenteric I/R, but it is still a question of debate whether selective COX-2 inhibitors can mitigate I/R-induced gut injury. Here we aimed to compare the effect of celecoxib and rofecoxib, two selective COX-2 inhibitors, on intestinal I/R-induced injury in rats.

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Artificial linear landscape elements, including roads, pipelines, and drainage channels, are main sources of global habitat fragmentation. Restoration of natural habitats on unused linear landscape elements can increase habitat quality and connectivity without interfering with agricultural or industrial development. Despite that topsoil removal and transfer are widely applied methods in restoration projects, up to our knowledge these were previously not compared in the same study system.

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Reversible protein phosphorylation regulates various cellular mechanisms in eukaryotes by altering the conformation, activity, localization, and stability of substrate proteins. In root meristems, histone post-translational modifications are crucial for proper cell division, and they are also involved in oxidative stress signaling. To investigate the link between reactive oxygen species (ROS) and mitosis, we treated various Arabidopsis genotypes, including wild-types and mutants showing dysfunctional PP2A, with the ROS-inducing herbicide diquat (DQ).

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Article Synopsis
  • PCDH19-related epilepsy primarily affects girls, starting around 15 months, often triggered by fever and marked by clustering of seizures, alongside symptoms like autism and intellectual disability.
  • A study reviewing nine children with genetically confirmed PCDH19 epilepsy in Hungary indicated a lower prevalence in their population compared to international figures, with several patients showing brain anomalies and a significant occurrence of status epilepticus.
  • Effective treatment with combined antiseizure medications was successful in seven out of nine children, highlighting the importance of genetic testing for early-onset seizures in females to improve diagnosis and treatment.
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Environmental heterogeneity shapes the patterns of resources and limiting factors and therefore can be an important driver of plant community composition through the selection of the most adaptive functional traits. In this study, we explored plant trait-environment relationships in environmentally heterogeneous microsite complexes at the meso-scale (few meters), and used ancient Bulgarian and Hungarian burial mounds covered by dry grasslands as a model habitat. We assessed within-site trait variability typical of certain microsites with different combinations of environmental parameters (mound slopes with different aspects, mound tops, and surrounding plain grasslands) using a dataset of 480 vegetation plots.

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Anterior thalamus (ANT) deep-brain stimulation (DBS) is an approved therapy for drug resistant epilepsy. We aimed to identify interictal epileptiform discharges (IED) in the ANT and to investigate their relationship with surface IEDs. Fifteen patients were monitored for two consecutive nights with externalized thalamic leads to analyze the intrathalamic epileptiform activities (TIED).

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Background: The use of left ventricular assist devices (LVADs) is increasing with an estimated 2500 devices implanted each year. When burdens of the LVAD outweigh benefits, most individuals with LVADs will undergo deactivation in the hospital setting. While the decision to deactivate an LVAD is considered an ethical practice, little is known about the experience and needs of bereaved family members.

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  • The study investigates the effects of halothane gas anesthesia on local field potentials (LFPs) in the caudate nucleus (CN) of cats, comparing anesthetized and awake animals.
  • Significant reductions in LFP power changes during visual stimulation were observed in anesthetized cats across different frequency ranges, particularly in static stimuli.
  • These findings highlight the importance of using awake, behaving animals for more accurate analyses of visually evoked neural signals.
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The existing plant trait databases' applicability is limited for studies dealing with the flora and vegetation of the eastern and central part of Europe and for large-scale comparisons across regions, mostly because their geographical data coverage is limited and they incorporate records from several different sources, often from regions with markedly different climatic conditions. These problems motivated the compilation of a regional dataset for the flora of the Pannonian region (Eastern Central Europe). PADAPT, the Pannonian Dataset of Plant Traits relies on regional data sources and collates data on 54 traits and attributes of the plant species of the Pannonian region.

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The cis-trans isomerization of amide bonds leads to wide range of structural and functional changes in proteins and can easily be the rate-limiting step in folding. The trans isomer is thermodynamically more stable than the cis, nevertheless the cis form can play a role in biopolymers' function. The molecular system of N-methylacetamide · 2H2O is complex enough to reveal energetics of the cis-trans isomerization at coupled cluster single-double and coupled cluster single-double and perturbative triple [CCSD(T)] levels of theory.

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Preprocessing is a mandatory step in electroencephalogram (EEG) signal analysis. Overcoming challenges posed by high noise levels and substantial amplitude artifacts, such as blink-induced electrooculogram (EOG) and muscle-related electromyogram (EMG) interference, is imperative. The signal-to-noise ratio significantly influences the reliability and statistical significance of subsequent analyses.

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In the Anthropocene, humans are among the most abundant long-distance seed dispersal vectors globally, due to our increasing mobility and the growing global population. However, there are several knowledge gaps related to the process of human-vectored dispersal (HVD) on clothing. In a multi-site field experiment covering various habitat types in three countries of Central-Europe, we involved 88 volunteer participants and collected 251 HVD samples and 2008 subsamples from their socks and shoes.

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Wood-pastures harbor critical natural and social values and are among the most ancient land use forms of Europe. The crucial conservation value of these silvopastoral systems is generally contributed to their characteristic landscape elements, the solitary trees, which provide microhabitats for a variety of organisms. However, by accommodating four habitat types (grasslands, solitary trees, forests, and forest edges) on a relatively small spatial scale, wood-pastures might host functionally and compositionally distinct arthropod communities, thus enhancing the landscape-level biodiversity.

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Colorectal cancer (CRC) has a high incidence and is one of the leading causes of cancer-related death. The accumulation of cancer-associated fibroblasts (CAF) induces an aggressive, stem-like phenotype in tumor cells, and it indicates a poor prognosis. However, cellular heterogeneity among CAFs and the targeting of both stromal and CRC cells are not yet well resolved.

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Patients with leukemia may occasionally suffer from rare opportunistic fungal infections with poor prognosis. Fungal infection caused by Geotrichum captitatum has not yet been described in Hungary. With this case report, we would like to draw attention to the fungal infection caused by G.

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Background: Recurrent genetic lesions provide basis for risk assessment in pediatric acute lymphoblastic leukemia (ALL). However, current prognostic classifiers rely on a limited number of predefined sets of alterations.

Methods: Disease-relevant copy number aberrations (CNAs) were screened genome-wide in 260 children with B-cell precursor ALL.

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Introduction: For people living with cerebral palsy, it is crucial to determine and monitor their quality of life because it indirectly can predict the completion of their needs and wishes, and their health-related conditions can be subjectively judged. Cerebral palsy is one of the the most common causes of childhood-onset, probably this is the reason why most quality of life studies focus on children and not on adolescents or adults.

Objectives: The aims of this study were to explore the quality of life of teenagers living with cerebral palsy receiving conductive education provided by the Pető András Faculty of Semmelweis University, and to map the differences and similarities between the perceptions of parents and their adolescent children.

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Pediatric acute myeloid leukemia (AML) represents a major cause of childhood leukemic mortality, with only a limited number of studies investigating the molecular landscape of the disease. Here, we present an integrative analysis of cytogenetic and molecular profiles of 75 patients with pediatric AML from a multicentric, real-world patient cohort treated according to AML Berlin-Frankfurt-Münster protocols. Targeted next-generation sequencing of 54 genes revealed 17 genes that were recurrently mutated in >5% of patients.

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Protein phosphatase PP2A is an enzyme complex consisting of C (catalytic), A (scaffold) and B (regulatory) subunits. B subunits are a large family of proteins that regulate activity, substrate specificity and subcellular localization of the holoenzyme. Knowledge on the molecular functions of PP2A in plants is less than for protein kinases, but it is rapidly increasing.

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Context: Massage therapy is increasingly used in palliative settings to improve quality of life (QoL) and symptom burden; however, the optimal massage "dosage" remains unclear.

Objectives: To compare three massage dosing strategies among inpatients receiving palliative care consultation.

Methods: At an urban academic hospital, we conducted a three-armed randomized trial examining three different doses of therapist-applied massage to test change in overall QoL and symptoms among hospitalized adult patients receiving palliative care consultation for any indication (Arm I: 10-min massage daily × 3 days; Arm II: 20-min massage daily × 3 days; Arm III: single 20-min massage).

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Several works of literature contributed to the web evaluation process in recent years to promote digital inclusion by addressing several accessibility guidelines, methods, processes, and techniques. Researchers have investigated how the web evaluation process could be facilitated by including accessibility issues to obtain an inclusive and accessible solution to improve the user experience and increase user satisfaction. Three systematic literature reviews (SLRs) have been conducted in the context of past research, considering such research focuses.

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The serine-threonine protein phosphatases PP2A regulate many cellular processes, however their role in oxidative stress responses and defence is less known. We show the involvement of its C (catalytic) and B" (a regulatory) subunits. The c3c4 (C subunit) and fass (B") subunit mutants and Col wt of Arabidopsis were used.

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Background: Burrowing mammals are important ecosystem engineers, especially in open ecosystems where they create patches that differ from the surrounding matrix in their structure or ecosystem functions.

Methods: We evaluated the fine-scale effects of a subterranean ecosystem engineer, the Lesser blind mole rat on the vegetation composition of sandy dry grasslands in Hungary. In this model system we tested whether the characteristics of the patch (mound size) and the matrix (total vegetation cover in the undisturbed grassland) influence the structural and functional contrasts between the mounds and the undisturbed grasslands.

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Article Synopsis
  • Scientists tested how different times for planting seeds affect how well flowers grow and how to keep weeds away in grasslands.
  • They did experiments in Hungary with different mixes of grass and flower seeds sown at various times, either right away or after one to three years.
  • They found that flowers grew better when sown in empty areas compared to already grassy places, and they should try planting flowers over several years instead of just once.
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