18F-fluorodeoxyglucose accumulation in the heart, brain and skeletal muscle of rats; the influence of time after injection, depressed lipid metabolism and glucose-insulin.

Background: To study the effect of lipid depressing drugs on (18)FDG myocardial concentration. The changes of (18)FDG uptake in myocardium, brain and skeletal muscle of rats were compared as influenced by acipimox, tyloxapol and glucose with insulin.

Material And Methods: 5.

Pretest clinical diagnosis of coronary artery disease and stress myocardial perfusion scintigram.

Background: To assess the probability of perfusion defects at exercise stress myocardial perfusion SPECT scintigraphy from pretest clinical diagnosis (medical personal history, previous ergometric investigation). To determine the value of clinical factors for probability of scintigraphic defects with respect to avoiding unnecessary investigation in subjects with low probability of abnormal scintigrams.

Material And Methods: 2143 subjects (1235 men, 908 women) were investigated by SPECT perfusion scintigraphy at stepwise increasing exercise stress.

[Transmyocardial laser revascularization of the myocardium and coronary reconstruction without extracorporeal circulation].

The authors report their experience with myocardial revacularization using transmyocardial laser revascularization combined with aortocoronary reconstruction without the use of extracorporeal circulation. The discussion section addresses indications for the procedure, operative tactics, the benefits and limitations of the above technique.

The effect of repeated strontium-89 chloride therapy on bone pain palliation in patients with skeletal cancer metastases.

One hundred and eighteen patients with painful skeletal metastases of malignant diseases (predominantly prostate, breast and lung cancer) were treated with 150 MBq of strontium-89 chloride (Metastron, Amersham, UK) intravenously. The results were evaluated according to a score considering pain relief, mobility, analgesic intake and general feeling. In only five patients (4.

Analysis of ventricular activation in patients with chronic non-Q wave myocardial infarction: comparison with left ventricular asynergy and myocardial perfusion defects.

In this report, we dealt with ventricular activation abnormalities in 30 patients with previous non-Q myocardial infarction (MI) by means of the CARDIAG 128.1 device, which enables analysis of ECGs, VCGs and body surface potential maps. The diagnosis was verified by left ventriculography, echocardiography and perfusion scintigraphy.

[Myocardial scintigraphy using 99m-Tc-methoxyisobutylisonitrile (Tc-MIBI): Is it equivalent to 201-Tl?].

The results of selective coronary angiography, myocardial 201-Tl scintigraphy (stress and redistribution) and after 99m-Tc-methoxyisobutylisonitrile stress and rest injections (Tc-MIBI, Cardiolite, DuPont de Nemours, USA) were compared in 19 patients with manifest ischemic heart disease in identical three projections and after same ergometric load. All three investigations were carried out within three consecutive days. 16 patients had significant stenoses of 1-3 main coronary arteries inclusive of left coronary artery main stem, insignificant stenoses (less than 50%) were present in remaining 3 patients.

Diagnosis of myocardial ischaemia by means of precordial ST mapping and exercise 201-thallium scintigraphy.

The authors compared the results of examination by means of exercise precordial ST mapping and exercise 201-thallium scintigraphy in 43 patients with ischaemic heart disease and in 10 controls. The methods have been found to be equally helpful in establishing the diagnosis of myocardial ischaemia. 201-thallium scintigraphy is preferred when trying to quantify the lesion and to localize it.

[The importance of 201Tl scintigraphy in stress tests for the diagnosis of silent myocardial ischemia].

Using thallium scintigraphy after a load (LTS), the authors tested suspected silent myocardial ischaemia (SIM) in subjects without angina pectoris. They examined 21 active pilots suspected of SIM after a previous ECG loading test (LET) and 33 patients with diabetes type I and II. In six pilots (28.

[Diagnosis of myocardial ischemia using functional ST mapping and 201Tl stress scintigraphy].

The authors compared the value of two non-invasive methods in the diagnosis of myocardial ischaemia, i.e. precordial working maps of the ST segment and working scintigraphy of the myocardium with 201T1 after a load.

[Topography of foci of perfusion defects after myocardial infarct on standard ECG and thallium stress scintigraphy].

65 patients after previous myocardial infarction well documented by electrocardiography were investigated by 201-Tl scintigraphy after submaximal ergometry. Topographic results of the scintigraphy in three planes were compared with the location of previous infarction demonstrated by standard electrocardiography. 30% of disagreements and partial agreements in more than half the patients were caused predominantly by inability of electrocardiography to qualify a true ischaemic necrosis in the interventricular septum, by limited ability to localize exactly the site of myocardial infarction and by underestimating its size, in particular in the posterior left ventricular wall, where the lesion often extends to the lateral wall.

A comparison of radionuclide and contrast left ventriculography and coronary angiography in patients after myocardial infarction.

61 patients after myocardial infarction were investigated by selective coronarography, contrast (LVG) and gated radionuclide ventriculography (RNV, rest and mild exercise). Left ventricular ejection fraction (LVGEF and RNVEF, resp.) and regional contractility disturbances were determined (in RNV by Fourier transform and factor analysis).

Determination of left ventricular wall motility injury by factor analysis in patients with advanced ischemic heart disease.

Left ventricular phase and amplitude images (Fourier analysis, PAI) and factor analysis images (FAI) from gated radionuclide ventriculography were obtained in 235 patients after myocardial infarction (MI) and in 44 patients with well documented ischemic heart disease (IHD) in order to assess areas of regional left ventricular motility injury (LVMI). The sensitivity of FAI for LVMI detection was higher than with PAI (36.3% vs 22.

Experimental regional myocardial ischaemia and myocardial uptake of potassium analogues; intercomparison of 42K, 86Rb and 201Tl.

The uptake of 42K, 86Rb and 201Tl by non-ischaemic and ischaemic myocardium was determined in rats with coronary artery ligature lasting 10, 30, 60 and 120 min, and in control rats without ischaemia. Whereas the myocardial concentration of 201Tl and 42K in control rats was similar and higher than that of 86Rb, 201Tl was superior to the other two radionuclides due to its significantly higher accumulation in non-ischaemic myocardium and the higher ratio of non-ischaemic to ischaemic radioactivity. The 86Rb accumulation in non-ischaemic myocardium and non-ischaemic/ischaemic ratio began to decrease from its maximum at 10 min.

Quantitative evaluation of valvular regurgitation by 133Xenon infusion.

Mitral and aortic regurgitation was evaluated by X-ray, dye dilution bolus, and 133Xenon infusion methods in 24 patients with mitral, aortic or both valve lesions. Good reproducibility was found using the 133Xenon infusion method. The regurgitant fraction estimated by 133Xenon constant infusion method correlates well with the results of the dye dilution method in mitral regurgitation as well as in aortic regurgitation.

The effect of some pathophysiological factors on radioisotope evaluation of regional myocardial ischaemia.

Scintigraphic demonstration of regional myocardial ischaemia is modified by some pathophysiological factors. Among 146 patients the percentage of angiographically visualized collaterals increased with the severity of coronary damage. The authors presume that collaterals diminish the hypoperfusion.

Renal blood flow distribution at varying perfusion pressure in the alloperfused dog kidney.

Tissue blood flow (TBF), its percent distribution and glomerular blood flow (GBF) were measured using labelled microspheres 15 micrometer in diameter (M) and chicken red blood cells (CRBC) at perfusion pressures (PP) of 17.3, 12.8 and 8.

Effects of oxyfedrine on left ventricular function in patients several months after myocardial infarction.

Left ventricular (LV) function was investigated by left heart catheterization at rest and during exercise in 15 men 3--5 months after acute myocardial infarction. The effect of 8 mg oxyfedrine i.v.

Changes of regional myocardial blood flow during and after acute focal experimental ischaemia.

The regional blood flow through the myocardium of the left ventricle was measured in 11 dogs after ligation of the left anterior descending coronary artery, by means of a local injection of 133Xe depot and precordial detection of its washout 2 hours after ligation. Immediately after ligation the blood flow in the ischaemic area declined considerably but at the same time there was a significant increase of blood flow in the non-ischaemic left ventricular myocardium. The regional flow in the ischaemic and non-ischaemic area increased insignificantly for 2 hrs.