Publications by authors named "K. Nahm"
Background: FXYD3 is a Na/K-ATPase modulator which is upregulated in pancreatic ductal adenocarcinoma (PDAC), but its prognostic role is unknown. This study evaluated FXYD3 expression in chemo-naive patients with surgically-resected PDAC at a single centre (1993-2014).
Method: FXYD3 expression was assessed in tumour specimens using immunohistochemistry.
Article Synopsis
- There is limited research linking breast MRI surveillance to the incidence of advanced second breast cancer in women with a personal history of breast cancer.
- A study conducted on women who underwent breast cancer surgery between 2009 and 2014 found that those who received MRI surveillance had significantly lower odds of developing advanced second breast cancer compared to those who did not.
- The findings suggest that surveillance breast MRI may be an effective tool for monitoring women with a personal history of breast cancer, potentially leading to earlier detection and better outcomes.
Pneumococcal vaccines are a cornerstone for the prevention of pneumococcal diseases, reducing morbidity and mortality in children and adults worldwide. Pneumococcal vaccine composition is based on the polysaccharide capsule of , which is one of the most important identified contributors to the pathogen's virulence. Similarities in the structural composition of polysaccharides included in licensed pneumococcal vaccines may result in cross-reactivity of immune response against closely related serotypes, including serotypes not included in the vaccine.
View Article and Find Full Text PDFInterleukin-33 (IL-33) is a proinflammatory alarmin cytokine released by damaged epithelial tissue cells that initiates and amplifies both type 1 and type 2 inflammatory cascades. A role for IL-33 in atopic dermatitis (AD; a chronic, relapsing type 2 inflammatory disease of the skin) has been proposed. Itepekimab is a novel human IgG4P monoclonal antibody against IL-33, currently in clinical development for chronic obstructive pulmonary disease (COPD).
View Article and Find Full Text PDFRecent Developments in (K, Na)NbO-Based Lead-Free Piezoceramics.
Micromachines (Basel)
February 2024
Article Synopsis
- * To enhance the piezoelectric properties of KNN ceramics, methods such as creating multistructures that facilitate domain rotation and using reactive-templated grain growth for specific grain orientation are explored.
- * The review focuses on the improvements in piezoelectric performance of [001]-textured KNN-based ceramics, noting that their microstructure
Article Synopsis
- Prurigo nodularis is a chronic skin disease causing intense itching, and nemolizumab, an IL-31 receptor antagonist, targets its underlying mechanisms.* -
- In a phase 3 trial, 274 adults with moderate-to-severe prurigo nodularis were given nemolizumab or a placebo for 16 weeks, showing significant improvements in itch and overall skin condition.* -
- Results revealed that 56.3% of the nemolizumab group reported reduced itching compared to 20.9% in the placebo group, with similar trends observed for other secondary outcomes, demonstrating its efficacy (P<0.001).*
Background: Congenital synostosis of the knee is a rare condition with limited data on treatment options and outcomes. This study reports clinical findings, treatment approach, and surgical/clinical outcomes for congenital synostosis of the knee.
Methods: An institutional review board-approved retrospective review of patients with congenital synostosis of the knee presenting to 2 institutions between 1997 and 2021 was performed.
Objective: Nonsurgical spinal decompression therapy (NSDT) is a conservative treatment for the lumbosacral herniated intervertebral disc (L-HIVD). This study aimed to evaluate the clinical effectiveness of the NSDT and change in disc volume through magnetic resonance imaging (MRI) in subacute L-HIVD.
Methods: Sixty patients with subacute L-HIVD were randomized into either the decompression group (group D, = 30) or the nondecompression group (group N, = 30).
We synthesized a series of slightly erbium-substituted yttrium iron garnets (Er:YIG), Y Er FeO at different Er concentrations ( = 0, 0.01, 0.05, 0.
View Article and Find Full Text PDFIntroduction: Since the introduction of pneumococcal conjugate vaccine, there have been warnings of an increase in infections caused by non-vaccine type of Streptococcus pneumoniae strains. Among them, nonencapsulated Streptococcus pneumoniae (NESp) has been reported to cause invasive infections, especially in children and the elderly. Due to low virulence, however, basic experimental reports on invasive infections are limited.
View Article and Find Full Text PDFBackground: Shortening and deformity of the tibia commonly occur during the treatment of congenital pseudarthrosis of the tibia (CPT). The role of osteotomies in lengthening and deformity correction remains controversial in CPT. This study evaluates the approach to and outcome after osteotomy performed in CPT.
View Article and Find Full Text PDFWe established an infant mouse model for colonization and transmission by nonencapsulated Streptococcus pneumoniae (NESp) strains to gain important information about its virulence among children. Invasive pneumococcal diseases have decreased dramatically since the worldwide introduction of pneumococcal capsular polysaccharide vaccines. Increasing prevalence of nonvaccine serotypes, including NESp, has been highlighted as a challenge in treatment strategy, but the virulence of NESp is not well understood.
View Article and Find Full Text PDFHighly pathogenic avian influenza (HPAI) is considered as one of the most devastating poultry diseases. It is imperative to immediately report any known outbreaks to the World Organization for Animal Health. Early detection of infected birds is of paramount importance to control virus spread, thus minimizing the associated economic loss.
View Article and Find Full Text PDFPurpose: Little is known about the clinical course of chronic urticaria (CU) and predictors of its prognosis. We evaluated CU patient clusters based on medication scores during the initial 3 months of treatment in an attempt to investigate time to remission and relapse rates for CU and to identify predictors for CU remission.
Methods: In total, 4,552 patients (57.
Piezoelectric energy harvesters (PEHs) aim to generate sufficient power to operate targeting device from the limited ambient energy. PEH includes mechanical-to-mechanical, mechanical-to-electrical, and electrical-to-electrical energy conversions, which are related to PEH structures, materials, and circuits, respectively; these should be efficient for increasing the total power. This critical review focuses on PEH structures and materials associated with the two major energy conversions to improve PEH performance.
View Article and Find Full Text PDFLattice defects typically reduce lattice thermal conductivity, which has been widely exploited in applications such as thermoelectric energy conversion. Here, an anomalous dependence of the lattice thermal conductivity on point defects is demonstrated in epitaxial WO thin films. Depending on the substrate, the lattice of epitaxial WO expands or contracts as protons are intercalated by electrolyte gating or oxygen vacancies are introduced by adjusting growth conditions.
View Article and Find Full Text PDFThe prevalence of nonencapsulated Streptococcus pneumoniae (NESp) has increased with the introduction of pneumococcal conjugate vaccines in children; however, the bacteriological characteristics of NESp have not been sufficiently clarified. In this study, NESp strains isolated from the nasopharyngeal carriage of children from four nursery schools in Japan were analyzed for molecular type, antibiotic susceptibility, and biofilm productivity. A total of 152 putative S.
View Article and Find Full Text PDFGroup B streptococcus (GBS) is a leading cause of young infant mortality and morbidity globally, with vaccines being developed for over four decades but none licensed to date. A serocorrelate of protection against invasive disease in young infants is being considered to facilitate vaccine early licensure, followed by demonstration of efficacy assessed postlicensure. In this Review, we synthesise the available scientific evidence to define an immune correlate associated with GBS disease risk reduction on the basis of studies of natural infection.
View Article and Find Full Text PDFA monolayer CaNbO (CNO) nanosheet was deposited on a Pt/Ti/SiO/Si substrate using the Langmuir-Blodgett method. This monolayer CNO nanosheet with a (001) surface termination was used as a seed layer to reduce the growth temperature of the crystalline (NaK )NbO (NKN) film. The crystalline NKN film was preferentially grown along the [001] direction at 400 °C.
View Article and Find Full Text PDFBackground: In this digital era, eHealth literacy is an essential skill set to leverage health information available online to promote health outcomes. South Korea has an advanced health information technology infrastructure, including widespread use of the internet and mobile phones. A few studies have explored eHealth literacy in South Korea using translated versions of the eHEALS; however, they were not fully validated.
View Article and Find Full Text PDFFe nuclear magnetic resonance (NMR) of magnetite nanocrystals ranging in size from 7 nm to 7 μm is measured. The line width of the NMR spectra changes drastically around 120 K, showing microscopic evidence of the Verwey transition. In the region above the transition temperature, the line width of the spectrum increases and the spin-spin relaxation time decreases as the nanocrystal size decreases.
View Article and Find Full Text PDFIntroduction: In vivo tracking of the transplanted stem cells is important in pre-clinical research of stem cell therapy for myocardial infarction. We examined the feasibility of adenovirus-mediated sodium iodide symporter (NIS) gene to cell tracking imaging of transplanted stem cells in a canine infarcted myocardium by clinical single photon emission computed tomography (SPECT).
Methods: Beagle dogs were injected intramyocardially with NIS-expressing adenovirus-transfected canine stem cells (Ad-hNIS-canine ADSCs) a week after myocardial infarction (MI) development.
Background: Use of the pneumococcal conjugate vaccine has led to serotype replacement of carriage and acute otitis media (AOM) pneumococcal isolates. Increases in nonencapsulated Streptococcus pneumoniae (NESp) isolates have also occurred, and there are increasing reports of NESp-associated disease. Disease prevalence and virulence factors of NESp isolates have not been studied.
View Article and Find Full Text PDFClassification and implementation of asthma phenotypes in elderly patients.
Ann Allergy Asthma Immunol
January 2015
Background: No attempt has yet been made to classify asthma phenotypes in the elderly population. It is essential to clearly identify clinical phenotypes to achieve optimal treatment of elderly patients with asthma.
Objectives: To classify elderly patients with asthma by cluster analysis and developed a way to use the resulting cluster in practice.