Publications by authors named "K-M Voit"
Sensory signals are transmitted via the thalamus primarily to layer 4 (L4) of the primary sensory cortices. While information about average neuronal connectivity in L4 is available, its detailed higher-order circuit structure is not known. Here, we used three-dimensional electron microscopy for a connectomic analysis of the thalamus-driven inhibitory network in L4.
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- A multi-institution collaboration was established to evaluate and compare different methods for measuring dystrophin levels in muscle biopsies, aiming for a reliable consensus and understanding of its clinical significance.
- Five expert laboratories conducted a detailed analysis of muscle samples using quantitative immunohistochemistry and Western blotting, ensuring standardized protocols to evaluate variability.
- The study found strong agreement in results across laboratories, with quantitative immunohistochemistry showing greater sensitivity, confirming that these methods can effectively measure dystrophin for clinical trials in Duchenne muscular dystrophy and aid in therapy development.