Publications by authors named "K van Rijn"
Article Synopsis
- The study aims to validate the MAGNIFI-CD index as an effective tool for monitoring treatment responses in patients with perianal fistulising Crohn's disease (pfCD).
- It analyzed data from 65 patients treated surgically or medically, showing a significant decrease in MAGNIFI-CD scores for those who responded to treatment and excellent agreement between two independent radiologists scoring the index.
- The research establishes key cut-off values for determining treatment responses, suggesting that the MAGNIFI-CD index is a reliable and responsive MRI scoring method for this condition.
A 27-year-old man underwent thoracic endovascular aortic repair for blunt thoracic aortic injury. Fourteen months later, he presented with intermittent paraplegia, congestive heart failure, and a decline of kidney function as a result of high-grade aortic stenosis caused by in-stent thrombosis. He had a concurrent infection with coronavirus disease 2019.
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- The PISA-II trial found that using short-term anti-TNF therapy followed by surgical closure results in better healing of perianal fistulas in Crohn's disease patients compared to anti-TNF therapy alone after 18 months.
- This study involved long-term follow-up of patients from the PISA-II trial, with data collected from 91 participants across multiple hospitals in the Netherlands and Italy, focusing on the effectiveness of each treatment method.
- Findings indicated that over a median follow-up period of 5.7 years, healing rates remained similar in both treatment groups, with a high percentage of participants remaining in the study.
Objectives: To evaluate the effect of bowel dilation on cine-MRI small bowel motility measurements, by comparing a conventional motility score (including bowel wall and lumen) with a bowel wall-specific motility score in healthy and diseased populations.
Methods: Four populations were included: 10 Crohn's patients with a stricture and prestricture dilation for segmental motility analysis, and 14 mannitol-prepared healthy subjects, 15 fasted healthy subjects and eight chronic intestinal pseudo-obstruction (CIPO) patients (characterized by dilated bowel loops) for global small bowel motility analysis. All subjects underwent a cine-MRI scan from which two motility scores were calculated: a conventional score (including bowel wall and lumen) and a bowel wall-specific score.
Background: Guidelines on Crohn's perianal fistulas recommend anti-tumour necrosis factor (TNF) treatment and suggest considering surgical closure for patients with surgically amenable disease. However, long-term outcomes following these two strategies have not been directly compared. The aim of this study was to assess radiological healing in patients who received short-term anti-TNF treatment and surgical closure compared with those who received anti-TNF treatment alone.
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