Publications by authors named "K van Holde"

Background: More research is needed to understand psychopathology among parents of children with mental disorders in the years before and after the child is diagnosed. Here, we estimated the risk of mental disorders and psychotropic medication use in parents of children with versus without mental disorders and the temporal associations between child and parental psychopathology.

Methods: We conducted a population-based matched cohort study using Danish register data.

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Article Synopsis
  • The study investigated adverse neonatal outcomes in children born to mothers with different eating disorders, including anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified (EDNOS).
  • It analyzed data from over 1.5 million births in Denmark from 1991 to 2015, comparing outcomes based on whether the eating disorder diagnosis was recent (within 2 years of conception) or past (over 2 years before conception).
  • Findings showed that recent eating disorders, especially AN, were linked to higher risks of low birthweight, small-for-gestational-age, and preterm birth, emphasizing the need for better prevention and monitoring of eating disorders during pregnancy.
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Eating disorders (EDs) commonly co-occur with other psychiatric and neurodevelopmental disorders including attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD); however, the pattern of family history and genetic overlap among them requires clarification. This study investigated the diagnostic, familial, and genetic associations of EDs with ADHD and ASD. The nationwide population-based cohort study included all individuals born in Denmark, 1981-2008, linked to their siblings and cousins.

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Background: Previous studies have indicated associations between maternal mental disorders and adverse birth outcomes; however, these studies mainly focus on certain types of mental disorders, rather than the whole spectrum.

Aims: We aimed to conduct a broad study examining all maternal mental disorder types and adverse neonatal outcomes which is needed to provide a more complete understanding of the associations.

Method: We included 1 132 757 liveborn singletons born between 1997 and 2015 in Denmark.

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Article Synopsis
  • This study examines the links between eating disorders (EDs), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD) in a large population from Denmark spanning those born between 1981 and 2008.
  • It found significantly higher risks for developing EDs in individuals diagnosed with either ADHD (almost double) or ASD (over two and a half times more likely).
  • Mediation analysis indicated that mood or anxiety disorders might explain a substantial portion of the relationship between ADHD or ASD and EDs, highlighting potential genetic links between anorexia nervosa and these conditions.
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