Publications by authors named "K van Dort"

Article Synopsis
  • HIV-1 modifies tetraspanins like CD9 to enhance its entry and replication within host cells, highlighting CD9's important role during infection.
  • Researchers created specialized nanobodies from llamas that target CD9, discovering several that bind effectively and have potential in combatting HIV-1.
  • These nanobodies didn't stop the initial virus lifecycle but were successful in preventing fusion of infected cells and reducing HIV-1 replication in immune cells, suggesting new treatment options alongside current antiretrovirals.
View Article and Find Full Text PDF
Article Synopsis
  • Antiretroviral treatment can't get rid of all the HIV in the body, and stopping treatment often doesn't help the immune system fight HIV.
  • Researchers looked at T cells, a type of immune cell, in people who don't get worse from HIV (long-term non-progressors) and found that their T cells worked better due to certain signals and activities.
  • The study suggests that problems with energy production in immune cells could lead to them not working properly against HIV, and improving this could help find better treatments to boost people's immune responses.
View Article and Find Full Text PDF

We present the results of a search for the b→dℓ^{+}ℓ^{-} flavor-changing neutral-current rare decays B^{+,0}→(η,ω,π^{+,0},ρ^{+,0})e^{+}e^{-} and B^{+,0}→(η,ω,π^{0},ρ^{+})μ^{+}μ^{-} using a 711  fb^{-1} data sample that contains 772×10^{6}  BB[over ¯] events. The data were collected at the ϒ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e^{+}e^{-} collider. We find no evidence for signal and set upper limits on branching fractions at the 90% confidence level in the range (3.

View Article and Find Full Text PDF

Background: Chronic immune activation is one of the hallmarks of human immunodeficiency virus (HIV) pathogenesis. Persistent upregulation of interferons (IFNs) and interferon-stimulated genes (ISGs) has previously been associated with chronic immune activation and HIV progression. Here a longitudinal analysis of the IFN and ISG response during HIV infection was performed to gain insights into the ongoing immune activation during HIV infection.

View Article and Find Full Text PDF

We measure the tau-to-light-lepton ratio of inclusive B-meson branching fractions R(X_{τ/ℓ})≡B(B→Xτν)/B(B→Xℓν), where ℓ indicates an electron or muon, and thereby test the universality of charged-current weak interactions. We select events that have one fully reconstructed B meson and a charged lepton candidate from 189  fb^{-1} of electron-positron collision data collected with the Belle II detector. We find R(X_{τ/ℓ})=0.

View Article and Find Full Text PDF