Therapeutic Potential of Combined 5% Lifitegrast and Tocopherol Eye Drops in Managing Inflammation and Oxidative Stress in Murine Dry Eye.

: This study aimed to evaluate the therapeutic effects of combined 5% lifitegrast (LF) and tocopherol (TCP) eye drops in a murine experimental dry eye (EDE) model. Female C57BL/6 were divided into seven groups: untreated controls, EDE control, EDE + 0.05% cyclosporin A (CsA), EDE + tocopherol (TCP), EDE + 5% LF, EDE + 5% LF + TCP (once daily), and EDE + 5% LF + TCP (twice daily).

C/EBPβ Regulates HIF-1α-Driven Invasion of Non-Small-Cell Lung Cancer Cells.

Metastatic cancer accounts for most cancer-related deaths, and identifying specific molecular targets that contribute to metastatic progression is crucial for the development of effective treatments. Hypoxia, a feature of solid tumors, plays a role in cancer progression by inducing resistance to therapy and accelerating metastasis. Here, we report that CCAAT/enhancer-binding protein beta (C/EBPβ) transcriptionally regulates () and thus promotes migration and invasion of non-small-cell lung cancer (NSCLC) cells under hypoxic conditions.

Multigas Identification by Temperature-Modulated Operation of a Single Anodic Aluminum Oxide Gas Sensor Platform and Deep Learning Algorithm.

Semiconductor metal oxide (SMO) gas sensors are gaining prominence owing to their high sensitivity, rapid response, and cost-effectiveness. These sensors detect changes in resistance resulting from oxidation-reduction reactions with target gases, responding to a variety of gases simultaneously. However, their inherent limitations lie in selectivity.

Evolving Characteristics of Type 2 Diabetes Mellitus in East Asia.

In East Asians, type 2 diabetes mellitus (T2DM) is primarily characterized by significant defects in insulin secretion and comparatively low insulin resistance. Recently, the prevalence of T2DM has rapidly increased in East Asian countries, including Korea, occurring concurrently with rising obesity rates. This trend has led to an increase in the average body mass index among East Asian T2DM patients, highlighting the influence of insulin resistance in the development of T2DM within this group.

Smart Bioelectronic Nanomesh Face Masks with Permeability and Flexibility for Monitoring Cortisol in Saliva.

Bioelectronic face masks can easily collect biomarkers in saliva, in which free cortisol is abundant. However, conventional bioelectronic face masks involve significant challenges in terms of permeability and inhalation due to their nonpermeable film-type structure. Herein, we introduce a flexible and permeable nanomesh-based wearable biosensor designed for bioelectronic face masks that monitor cortisol levels.