Ultrahigh concentration exfoliation and aqueous dispersion of few-layer graphene by excluded volume effect.

Colloidal properties of nanoparticles are intricately linked to their morphology. Traditionally, achieving high-concentration dispersions of two-dimensional (2D) nanosheets has proven challenging as they tend to agglomerate or re-stack under increased surface contact and Van der Waals attraction. Here, we unveil an excluded volume effect enabled by 2D morphology, which can be coupled with electrostatic repulsion to synthesize high-concentration aqueous graphene dispersions.

Human blood metabolites and gastric cancer: a Mendelian randomization analysis.

Background: Gastric cancer (GC) remains one of the predominant malignant tumors within the digestive tract, yet its underlying biological mechanisms remain elusive. The primary objective of this study is to delineate the causal relationship between circulating metabolites and GC.

Method: The primary Mendelian randomization (MR) analysis was based on three large GWAS datasets.

Exercise electrocardiogram combined with cadmium zinc tellurium (CZT) cardiac-dedicated single photon emission computed tomography (SPECT) predicts coronary artery disease.

Aim: Coronary artery disease (CAD) is a primary cause of mortality, prompting ongoing research into noninvasive diagnostic modalities. This study aimed to evaluate the diagnostic efficacy of exercise electrocardiography testing (EET) combined with cadmium zinc tellurium cardiac-dedicated single photon emission computed tomography (CZT-SPECT) imaging for CAD.

Materials And Methods: CZT-SPECT and EET were examined in 124 patients aged 20-85 years, followed by coronary angiography to evaluate the sensitivity, specificity, positive predictive value, and negative predictive value of EET/CZT-SPECT alone and in combination.

Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy.

Background: Developmental and epileptic encephalopathies (DEE) are rare but severe neurodevelopmental disorders characterised by early-onset seizures often combined with developmental delay, behavioural and cognitive deficits. Treatment for DEEs is currently limited to seizure control and provides no benefits to the patients' developmental and cognitive outcomes. Genetic variants are the most common cause of DEE with KCNQ2 being one of the most frequently identified disease-causing genes.

Comparison of DWI techniques in patients with epidermoid cyst: TGSE-BLADE DWI vs. SS-EPI DWI.

Purpose: To compare quantitative values and image quality between single-shot echo-planar imaging (SS-EPI) diffusion-weighted imaging (DWI) and two-dimensional turbo gradient- and spin-echo DWI with non-Cartesian BLADE trajectory (TGSE-BLADE DWI) in patients with epidermoid cyst.

Methods: Patients with epidermoid cyst who underwent both SS-EPI DWI and TGSE-BLADE DWI were included in this study. Two raters placed ROIs encircling the entire epidermoid cyst on SS-EPI DWI, and then on TGSE-BLADE DWI.