Publications by authors named "K Zglejc-Waszak"
Chronotypes play a crucial role in regulating sleep-wake cycles and overall health. The aim of this study was to investigate chronotype, sleep quality, polymorphisms of clock genes and the level of leptin in serum. We used standardized questionnaires to assess chronotype and sleep quality.
View Article and Find Full Text PDFEndometrial cancer (EC) is the most common gynecological malignancy. EC is associated with metabolic disorders that may promote non-enzymatic glycation and activate the receptor for advanced glycation end-products (RAGE) signaling pathways. Thus, we assumed that RAGE and its ligands may contribute to EC.
View Article and Find Full Text PDFAmyotrophic lateral sclerosis (ALS) is neurodegenerative disease characterized by a progressive loss of motor neurons resulting in paralysis and muscle atrophy. One of the most prospective hypothesis on the ALS pathogenesis suggests that excessive inflammation and advanced glycation end-products (AGEs) accumulation play a crucial role in the development of ALS in patients and SOD1 G93A mice. Hence, we may speculate that RAGE, receptor for advanced glycation end-products and its proinflammatory ligands such as: HMGB1, S100B and CML contribute to ALS pathogenesis.
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- Diabetic peripheral neuropathy (DPN) is linked to disruptions in the RAGE-Diaph1 signaling pathway, affecting both peripheral nerves and the spinal cord.
- In type 1 diabetes, significant molecular changes were found in the spinal cord, with over 500 differentially expressed genes, highlighting the PI3K-Akt pathway as most affected.
- Cathepsin E emerges as a potential key target for treating DPN, with limited overlap in gene changes between the sciatic nerve and spinal cord in diabetic mice.
This review focuses on receptor for advanced glycation endproducts/diaphonous related formin 1 (RAGE/Diaph1) interaction as a modulator of actin cytoskeleton dynamics in peripheral nervous system (PNS) in diabetes. Deciphering the complex molecular interactions between RAGE and Diaph1 is crucial in expanding our understanding of diabetic length dependent neuropathy (DLDN). DLDN is a common neurological disorder in patients with diabetes.
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