Insight into Antimicrobial Properties via Self-Acidification of Compounds from the Molybdenum-Tungsten-Oxygen System.

This communication is focused on the synthesis, characterization and experimental proof of the mechanism of antimicrobial activity of powders from the molybdenum-tungsten-oxygen (Mo-W-O) system. Materials with a discrete ratio of Mo/W ranging from 100% MoO to 100% WO with a stepwise increase of 5-10 wt % W were synthesized by the spray drying method following calcination. Spherical hollow particles with a broad size distribution were formed and the composition influenced the crystalline phases in such a way that either pure and/or mixed oxides (MoWO) were obtained.

Silver-, calcium-, and copper molybdate compounds: Preparation, antibacterial activity, and mechanisms.

Developing novel compounds with antimicrobial properties can be an effective approach to decreasing the number of healthcare-associated infections, particularly in the context of medical devices and touch surfaces. A variety of molybdate powders (AgMoO, CaMoO, CuMoO and CuMoO) were synthesized and characterized, and Escherichia coli was used as a model gram-negative bacterium to demonstrate their antimicrobial properties. Optical density measurements, bacterial colony growth, and stained gel images for protein expression clearly showed that silver- and copper molybdates inhibit bacterial growth, whereas CaMoO exhibited no bactericidal effect.

Orthogonally protected artificial amino acid as tripod ligand for automated peptide synthesis and labeling with [(99m)Tc(OH(2))(3)(CO)(3)](+).

1,2-Diamino-propionic acid (Dap) is a very strong chelator for the [(99m)Tc(CO)(3)](+) core, yielding small and hydrophilic complexes. We prepared the lysine based Dap derivative l-Lys(Dap) in which the ε-NH(2) group was replaced by the tripod through conjugation to its α-carbon. The synthetic strategy produced an orthogonally protected bifunctional chelator (BFC).

Spectroscopic, morphological, and mechanistic investigation of the solvent-promoted aggregation of porphyrins modified in meso-positions by glucosylated steroids.

Solvent-driven aggregation of a series of porphyrin derivatives was studied by UV/Vis and circular dichroism spectroscopy. The porphyrins are characterised by the presence in the meso positions of steroidal moieties further conjugated with glucosyl groups. The presence of these groups makes the investigated macrocycles amphiphilic and soluble in aqueous solvent, namely, dimethyl acetamide/water.

Coordination chemistry and biological activity of 5'-OH modified quinoline-B12 derivatives.

The consequences of structural modifications at the 5'-OH ribofuranotide moiety of quinoline modified B12 derivatives are discussed in regard of the coordination chemistry, the electrochemical properties and the biological behaviour of the compound.