Three-dimensional genome architecture in intrahepatic cholangiocarcinoma.

Purpose: Intrahepatic cholangiocarcinoma (ICC) is a common primary hepatic tumors with a 5-year survival rate of less than 20%. Therefore, it is crucial to elucidate the molecular mechanisms of ICC. Recently, the advance of high-throughput chromosome conformation capture (Hi-C) technology help us look insight into the three-dimensional (3D) genome structure variation during tumorigenesis.

Retroperitoneal laparoscopic partial nephrectomy for multiple T1b renal carcinomas in a solitary kidney: A case report.

This case highlights the effective use of retroperitoneal laparoscopic partial nephrectomy (RLPN) in a 73-year-old female with two large renal carcinomas in her solitary kidney, including a 7 cm deeply infiltrating mass. The RLPN procedure successfully resected both tumors with a thermal ischemia time of 28 minutes, 110 minutes of surgery, and only 30 mL of blood loss. The patient's postoperative recovery was excellent, with no hemorrhage or urine leakage and only a mild increase in serum creatinine levels.

Prevalence of Insomnia and Related Factors Among Cancer Outpatients in China.

Background: The incidence of insomnia in cancer patients is significantly higher than in the general population. Chronic insomnia imposes pronounced physical and psychological burdens on cancer patients, affecting their quality of life and survival rate. This study aims to investigate insomnia in cancer patients and further analyze potentially related factors.

Nitrogen fertilizer application for improving the biomass, quality, and nitrogen fixation of alfalfa ( L.) at different growth stages in a saline‒alkali soil.

Background: The application of nitrogen (N) fertilizer to alfalfa ( L.) has received little attention due to the ability of this plant to fix N. However, N deficiency stress is often observed in marginal lands of China, especially in saline-alkali soils.

Built-in electric field in the Mn/C heterojunction promotes electrocatalytic nitrogen reduction to ammonia.

The electrochemical nitrogen reduction reaction (NRR) has been regarded as a green and promising alternative to the traditional Haber-Bosch process. However, the high bond energy (940.95 kJ mol) of the NN triple bond hinders the adsorption and activation of N molecules, which is a critical factor restricting the catalytic performance of catalysts and their large-scale applications.