Publications by authors named "K Z Kuhn"

Unlabelled: Studies have suggested that phytochemicals in green tea have systemic anti-inflammatory and neuroprotective effects. However, the mechanisms behind these effects are poorly understood, possibly due to the differential metabolism of phytochemicals resulting from variations in gut microbiome composition. To unravel this complex relationship, our team utilized a novel combined microbiome analysis and metabolomics approach applied to low complexity microbiome (LCM) and human colonized (HU) gnotobiotic mice treated with an acute dose of powdered matcha green tea.

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Article Synopsis
  • Spondyloarthritis (SpA) is a common condition among patients with inflammatory bowel disease (IBD), affecting up to 39% of individuals but lacks well-defined risk factors.
  • The study involved assessing 588 IBD patients using two validated questionnaires to identify SpA symptoms, revealing significant positive screenings for SpA among these patients.
  • Key risk factors for positive SpA screens included being female, older age, a history of smoking, bowel surgery, and exposure to biologic treatments, with a concerning number of undiagnosed cases identified.
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Article Synopsis
  • Spondyloarthritis (SpA) is a common issue for patients with inflammatory bowel disease (IBD), and using specific screening tools could help identify it earlier and improve treatment.
  • A study analyzed 669 IBD patients using two questionnaires (DETAIL and IBIS-Q) to check for SpA symptoms; many patients screened positive, with more showing axial symptoms rather than peripheral issues.
  • The results highlighted that a significant number of patients with IBD might have undiagnosed SpA, particularly with the IBIS-Q being more effective in identifying potential cases, indicating a need for better rheumatology referrals for these patients.
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Objective: Various facultative pathogenic bacteria have been detected in the dog's prepuce. To prevent the transmission of these bacteria, some breeders flush the prepuce of their stud dogs before mating. The purpose of this study is to find out whether preputial flushing is medically useful before mating.

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Studies have suggested that phytochemicals in green tea have systemic anti-inflammatory and neuroprotective effects. However, the mechanisms behind these effects are poorly understood, possibly due to differential metabolism of phytochemicals resulting from variation in gut microbiome composition. To unravel this complex relationship, our team utilized a novel combined microbiome analysis and metabolomics approach applied to low complexity microbiome (LCM) and human colonized (HU) gnotobiotic mice treated with an acute dose of powdered matcha green tea.

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