Publications by authors named "K Yuge"
Article Synopsis
- - The study explores how temperature affects the plastic deformation of single crystals from quaternary and ternary medium-entropy alloys (MEAs) within the Cr-Mn-Fe-Co-Ni system, focusing on compression tests across a wide temperature range.
- - It was found that critical resolved shear stresses (CRSSs) increase as temperatures drop, with a unique behavior below 77 K attributed to dislocation dynamics influenced by phonon interactions.
- - The research indicates that the temperature dependence of CRSS is consistent with established theories for face-centered cubic alloys and reveals additional complexities at elevated temperatures, including solute-dislocation interactions, while providing comparisons with previous studies on high-entropy alloys.
Background: Until recently, the treatment of spinal muscular atrophy (SMA) was limited to symptomatic treatment with no cure. Three innovative drugs, nusinersen, onasemnogene abeparvovec (OA), and risdiplam have been developed to treat SMA. Although the clinical trials for these drugs have demonstrated their efficacy, there is limited information on real world treatment strategies.
View Article and Find Full Text PDFSpinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by the deletion or mutation of the survival motor neuron 1 (SMN1) gene. The establishment of effective newborn screening (NBS) for SMA is important for early diagnosis so that treatment can be administered in the pre-symptomatic or early disease stages. Polymerase chain reaction (PCR)-based genetic testing with dried blood spots has been used in NBS to detect the homozygous deletion of exon 7 in SMN1, however, this methodology is not able to detect newborn infants with heterozygous deletions and/or point mutations in SMN1.
View Article and Find Full Text PDFBackground/aim: Hepatic recurrences after resection of metastatic lesions in advanced colorectal cancer (CRC) have an enormous impact on patient prognosis. Response evaluation criteria in solid tumor (RECIST) or morphologic response on computed tomography (CT) have been reported as surrogate prognostication markers. This study assessed a novel algorithm for the prognostication of liver metastasis treatment.
View Article and Find Full Text PDFIntroduction: Reports on the long-term quality of life (QOL) over 3 years after surgery in patients who have undergone surgery for rectal cancer are limited. Therefore, we aimed to evaluate the long-term QOL of patients who underwent high anterior resection (HAR), low anterior resection (LAR), internal sphincter resection (ISR), or abdominoperineal resection (APR) for rectal cancer.
Methods: A questionnaire regarding QOL was sent to 360 patients with rectal cancer who underwent curative resection by HAR, LAR, ISR, or APR between January 2005 and December 2015.