Publications by authors named "K Yonemoto"
Background/aim: Costal cartilage fractures are associated with poor prognosis in patients with blunt chest trauma. A Computer-Aided Detection (CAD) system for detecting rib fractures has been used in practice, but it is unclear whether this system recognizes costal cartilage fractures. This study investigated whether the CAD system for rib fracture can detect costal cartilage fractures.
View Article and Find Full Text PDFBackground: Postoperative aortobronchial fistula (ABF) is a rare complication that can occur in 0.3%-5.0% of patients over an extended period of time after thoracic aortic surgery.
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- GNAO1 encodes a protein involved in brain development, and its mutations lead to serious neurological issues such as developmental delays and seizures in infants.
- Research shows that reducing Gnao1 levels disrupts important signaling pathways and affects neuron growth, particularly in cells from patients with specific mutations.
- The study suggests that targeting the Rho GTPase pathway could be a potential therapeutic strategy for treating GNAO1-associated encephalopathy.
Background: In aged society, health policies aimed at extending healthy life expectancy are critical. Maintaining physical activity is essential to prevent the deterioration of body functions. Therefore, it is important to understand the physical activity levels of the target age group and to know the content and intensity of the required physical activity quantitatively.
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- The Shank3 gene, linked to autism, has several isoforms (Shank3a-f) and knockout mice lacking Shank3a/b show heightened seizure susceptibility.
- Researchers conducted a proteomic analysis that identified 348 proteins interacting with the N-terminal and ankyrin repeat domains of Shank3a/b, highlighting significant associations with RNA-binding proteins and components involved in splicing and ribosomes.
- The interaction between Shank3 and the protein Nono was validated, and knockout mice also displayed abnormal splicing of autism-related genes, suggesting Shank3 regulates RNA-binding protein interactions and gene expression in the developing brain.