Publications by authors named "K Yokomizo"
Ipomoea alba L. (Convolvulaceae) is an annual vine native to tropical America that is cultivated primarily for ornamental purposes. Its seeds are used in traditional medicine as a laxative, and young shoots are consumed as food.
View Article and Find Full Text PDFPurpose: The purpose of this study was to investigate the bacterial composition in the conjunctiva and to determine the relationship between fluoroquinolone resistance and mutations in the quinolone resistance-determining region (QRDR) in Corynebacterium macginleyi (C. macginleyi).
Methods: Bacteria isolated from conjunctival swabs of patients awaiting ophthalmic surgery or patients with presumed keratoconjunctivitis were included in this study.
Article Synopsis
- Dendritic cells (DCs) play a crucial role in starting immune responses by presenting antigens to T lymphocytes, but the effects of tomato-derived saponin Esculeoside A (EsA) on these cells were not well understood.
- This study found that EsA and its related compound, esculeogenin A (Esg-A), reduced the maturation and function of mice bone marrow-derived DCs when stimulated by lipopolysaccharide (LPS), leading to less efficient T-cell activation.
- The research also highlighted that EsA/Esg-A inhibited key signaling pathways involved in immune response, suggesting potential therapeutic applications for modulating DCs in immune-related conditions.
Gastric cancer (GC) is a globally prevalent and deadly malignancy often diagnosed at advanced stages, which can be accompanied by liver metastases. Conventional chemotherapy is contraindicated in patients with severe liver failure because several chemotherapeutic agents are metabolized by the liver. The present study reports on the successful use of nivolumab in a patient with advanced GC and severe liver failure owing to multiple liver metastases.
View Article and Find Full Text PDFIpomoea muricata (L.) Jacq. seeds (Convolvulaceae) are used as a traditional laxative and carminative medicine.
View Article and Find Full Text PDF