Publications by authors named "K Yeong"
Scaffold-based drug design has become increasingly prominent in the pharmaceutical field due to the systematic and effective approach through which it facilitates the development of novel drugs. The identification of key scaffolds provides medicinal chemists with a fundamental framework for subsequent research. With mounting evidence suggesting that increased aromaticity could impede the chances of developmental success for oral drug candidates, there is an imperative need for a more thorough exploration of alternative ring systems to mitigate attrition risks.
View Article and Find Full Text PDFAlzheimer's disease is a significant global health issue, and studies suggest that neuroinflammation plays a vital role in the advancement of this disease. In this study, anakinra has been shown to display a time- and concentration-dependent antineuroinflammatory effect. In the studies, it diminished the gene expressions of tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO) synthase 2 stimulated by lipopolysaccharide (LPS).
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- Originally, cyclic sulfonamide (sultam) and its derivatives were mainly researched for their antibacterial properties.
- Recently, there has been increased interest in their potential uses as anticancer, anti-inflammatory, antidiabetic, and antiviral agents.
- Although this area of research shows promise, only a few sultam drugs are available commercially, as much of the work is still in the discovery phase, prompting this review to focus on the biological activities of different sultam derivatives.
Article Synopsis
- A 66-year-old man with no prior abdominal surgeries experienced severe abdominal pain and vomiting, leading to a diagnostic laparoscopy which revealed a closed-loop obstruction due to a lateral type pericecal hernia.
- The surgery uncovered ischemic jejunum and adhesion bands, and the patient recovered well after appropriate surgical intervention.
- The case highlights the need for prompt diagnosis and treatment of pericecal hernias, along with discussing classification, causes, symptoms, and the advantages of using laparoscopy in such cases.
Nucleobases serve as essential molecular frameworks present in both natural and synthetic compounds that exhibit notable antiviral activity. Through molecular modifications, novel nucleobase-containing drugs (NCDs) have been developed, exhibiting enhanced antiviral activity against a wide range of viruses, including the recently emerged SARS‑CoV‑2. This article provides a detailed examination of the significant advancements in NCDs from 2015 till current, encompassing various aspects concerning their mechanisms of action, pharmacology and antiviral properties.
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