Publications by authors named "K Yasukawa"
CYP105A1 exhibits monooxygenase activity to a wide variety of structurally different substrates with regio- and stereospecificity, making its application range broad. Our previous studies have shown that CYP105A1 wild type and its variants metabolize 12 types of nonsteroidal anti-inflammatory drugs (NSAIDs). In particular, the R84A variant exhibited a high activity against many NSAIDs.
View Article and Find Full Text PDFIn mammals, intestinal α-glucosidase exists as a maltase-glucoamylase complex (MGAM) and a sucrase-isomaltase complex (SI). In this study, we transiently expressed human MGAM and SI in human embryonic kidney 293 (HEK293) cells. At pH 6.
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- Histone lactylation is a new epigenetic modification driven by lactate from glycolysis, which is often heightened in cancer, notably gastric cancer (GC), and is linked to poorer patient outcomes.
- In GC, increased levels of histone H3K18 lactylation correlate with worse prognosis, while SIRT1 plays a key role in regulating these levels by either promoting or diminishing H3K18la depending on its expression.
- Targeting the interplay between SIRT1, the lncRNA H19, and glycolysis presents a promising therapeutic approach for GC, showing significant anti-cancer effects while minimizing harm to normal cells.
Background: The Naples prognostic score (NPS) is a remarkable marker of short- and long-term outcomes in various types of cancer. However, its impact on the postoperative outcomes of hepatocellular carcinoma remains controversial. This study aimed to clarify the impact of the NPS on the prognosis and incidence of postoperative complications in hepatocellular carcinoma.
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- Ophthalmic diseases, commonly affecting the elderly, often go untreated due to limited resources and decreased daily activities, highlighting the need for better eye care, especially in home settings.
- A study was conducted on Miyako Island, Japan, using portable equipment to examine 147 home-based patients, revealing various eye conditions, particularly cataracts, with over half of those affected not having undergone surgery.
- The findings emphasize the importance of improving eye care systems in remote areas to prevent complications like glaucoma and ensure better access to treatment for elderly patients.