Publications by authors named "K Yashin"
: Glioblastoma (GB) is a highly aggressive tumor, whose progression is mediated by secretion of extracellular vesicles (EVs), which can pass the brain-blood barrier and be found in the plasma. Here, we performed a comparative analysis of the effects of EVs from the plasma of healthy donors (hEVs) and GB patients before (bEVs) and after (aEVs) tumor surgical resection on invasion of normal astrocytes and GB cells. : We performed the transwell invasion assay, analyzed MAP kinases activation by Western blotting, studied SNAI1/SNAI2 cellular localization by confocal microscopy, measured cadherins expression by flow cytometry, and analyzed secretion of cytokines, which regulate migration and inflammation, by immunoassay.
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- The research investigates how different types of glial tumors in rats affect the attenuation coefficient of white matter in the brain, showing varied impacts based on tumor type and malignancy.
- Some tumors lead to a significant drop in this coefficient due to cell infiltration and damage to myelinated fibers, while others compress fibers without major destruction.
- The study also highlights the potential of using the attenuation coefficient, derived from OCT data, to identify late radiation damage in white matter, suggesting its usefulness for evaluating tissue health around tumors during surgeries.
A peritumoral brain zone is an area between a tumor and nontumorous brain tissue with tumor cell infiltration. The identification of this area is sufficiently difficult due to the lack of clear morphological or some other criteria. Besides, its dimensions may vary considerably.
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- The study looked at how well patients recover their language skills after having brain surgery for a type of tumor on the left side of the brain.
- Researchers tested 59 patients' language abilities before surgery, right after, and several months later to see how they changed.
- They found that while some patients didn't recover well, better immediate language mapping during surgery helped with recovery, especially in areas like understanding sentences and using verbs.
How aging affects cells of the human brain active milieu remains largely unknown. Here, we analyze astrocytes and neurons in the neocortical tissue of younger (22-50 years) and older (51-72 years) adults. Aging decreases the amount of reduced mitochondrial cytochromes in astrocytes but not neurons.
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