Publications by authors named "K Yahiro"
is an important foodborne pathogen. Cholix cytotoxin (Cholix), produced by , is a novel eukaryotic elongation factor 2 (eEF2) adenosine diphosphate ribosyltransferase that causes host cell death by inhibiting protein synthesis. However, the role of Cholix in the infectious diseases caused by remains unclear.
View Article and Find Full Text PDFUnlabelled: imaging of bacterial infection models enables noninvasive and temporal analysis of individuals, enhancing our understanding of infectious disease pathogenesis. Conventional imaging methods for bacterial infection models involve the insertion of the bacterial luciferase LuxCDABE into the bacterial genome, followed by imaging using an expensive ultrasensitive charge-coupled device (CCD) camera. However, issues such as limited light penetration into the body and lack of versatility have been encountered.
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- Endotoxins (LPS) are problematic in bacterial protein production, but researchers developed a method using a special bacterium that lacks LPS.
- They successfully created endotoxin-free proteins, including functional green fluorescent protein and the cytokine TNF-α, and significantly reduced contamination levels.
- This new system also enabled the production of a specific antibody targeting the coronavirus spike protein and a rheumatoid arthritis drug, showcasing its potential for future applications in biotechnology.
Article Synopsis
- The study focuses on understanding the function of the PmrAB two-component system (TCS) in resistance to colistin, a last-resort antibiotic, in extensively drug-resistant (XDR) Gram-negative bacteria.
- Researchers conducted transcriptome analysis to identify the regulatory genes controlled by PmrAB, revealing its responsiveness to environmental factors like pH and metal ions (Fe, Zn, Al).
- The findings highlight PmrAB's role in both environmental adaptation and the development of antibiotic resistance by modifying lipooligosaccharide (LOS) to mitigate toxicity and enhance resistance to colistin and polymyxin B.
We identify a new class of distributional constraints defined as a union of symmetric M-convex sets, which can represent a wide range of real-life constraints in two-sided matching settings. Since M-convexity is not closed under union, a union of symmetric M-convex sets does not belong to this well-behaved class of constraints. Consequently, devising a fair and strategyproof mechanism to handle this new class is challenging.
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