Publications by authors named "K Yagita"
Altered expression of human myxovirus resistance protein A in amyotrophic lateral sclerosis.
J Neuropathol Exp Neurol
September 2024
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. The etiology of sporadic ALS (sALS) has not yet been clarified. An increasing body of evidence suggests the involvement of viral infections and interferons (IFNs).
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- Prion disease is a serious neurodegenerative illness, with definitive diagnosis relying on detecting resistant prion proteins through Western blotting.
- This study focused on identifying prion proteins in formalin-fixed paraffin-embedded samples from various prion disease cases, confirming the presence and type of prion proteins in specific diseases like sporadic Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease.
- The findings suggest that analyzing these FFPE specimens allows for safe detection and classification of prion diseases, aiding both diagnosis and research efforts.
The hypothalamus is the region of the brain that integrates the neuroendocrine system and whole-body metabolism. Patients with Alzheimer's disease (AD) have been reported to exhibit pathological changes in the hypothalamus, such as neurofibrillary tangles (NFTs) and amyloid plaques (APs). However, few studies have investigated whether hypothalamic AD pathology is associated with clinical factors.
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- Chronic jet-lag (CJL) affects wild-type mice differently, leading to varying levels of liver fat accumulation and highlighting the need for understanding these individual differences for better disease prevention.
- Researchers combined various methods, such as examining physiological and gene expression patterns, to identify how CJL impacts lipid metabolism and overall health in mice.
- The study found that stronger circadian rhythms in mice are linked to fewer health issues from CJL, suggesting that understanding these rhythms could help predict and manage circadian-related diseases.
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- The study aimed to explore the circadian rhythms in the trigeminal ganglion of mice, which are relevant to understanding headache disorders like migraines and cluster headaches.
- Researchers used a combination of ex vivo and single-cell cultures, along with behavioral and genetic analyses, to assess the influences of these rhythms on pain sensitivity in a nitroglycerin-induced headache model.
- Results revealed significant circadian patterns in gene expression and pain sensitivity, including the identification of potential gene targets for therapies that align with these rhythms.