Detachable Top Electrode-Organic Photodetector for Repeated Nondestructive Evaluation of Device Performance and Surface Analysis of the Active Layer.

Organic photodetectors (OPDs) are key devices for monitoring vital signs, such as heart rate and blood oxygen level. For realizing the long-term measurement of biosignals, stable operation is essential. To improve the stability of OPDs, it is important to analyze each layer to understand the degradation mechanism.

Pharmacist Intervention in Outpatients With Prostate Cancer Prevents Apalutamide-induced Skin Adverse Events.

Background/aim: Apalutamide induces severe skin adverse events (sAEs) in 14.7% of Japanese patients, leading to treatment discontinuation. To maximize the management of sAEs in patients taking apalutamide for prostate cancer, we conducted pharmacist outpatient clinics for patients receiving apalutamide in the outpatient setting.

Consumption of Sodium and Its Ratio to Potassium in Relation to All-Cause, Cause-Specific, and Premature Noncommunicable Disease Mortality in Middle-Aged Japanese Adults: A Prospective Cohort Study.

Background: Reducing premature noncommunicable disease (NCD) mortality is a global challenge. Sodium is thought to increase risk of NCDs via an effect of salt per se or high-salt foods on hypertension-induced cardiovascular disease (CVD) and gastrointestinal cancer. Further, relative risk of CVD is reportedly more closely associated with sodium-to-potassium ratio than that with sodium alone.

Application of 4'--α-aminoethoxy-2'--methyl-5-propynyl-uridine for antisense therapeutics.

Owing to the increased public interest and advances in chemical modifications, the approval of antisense therapeutics, a class of mRNA-targeting DNA-based oligonucleotide therapeutics, has accelerated in recent years. It was previously reported that siRNAs with several 4'--α-aminoethoxy-2'--methyl-uridine (4AEoU) analogs could maintain moderate thermal stability similar to the native ones while showing robust nuclease stability. In this study, we further expanded the application of 4AEo modification to antisense therapeutics and achieved superior thermal stability by adding the uracil 5-propynyl modification.

Review of the family Vanhorniidae (Hymenoptera: Proctotrupoidea), with the description of two new species.

World species of the genus Vanhornia, the only member of Vanhorniidae, are reviewed and six species are recognized. Two new species, V. formosana sp.