[The role of released membrane microparticles in pathogenesis of systemic inflammatory response].

The aim of this work was to evaluate contribution of released membrane particles (RMP) to the development of systemic inflammatory response (SIR) after aortocoronary bypass grafting (ACBG). The number of RMP carrying surface adhesion molecules, CD62L, CD62P, CD62E, was shown to increase in the early postoperative period in parallel with the enhancement of lymphocyte plasma membrane blebbing and elevation of cytokine levels in peripheral blood. It is concluded that (1) activation of plasma membrane blebbing in peripheral blood cells underlies the appearance of RMP in circulation; (2) increased number of RMP expressing CD62L, CD62P, CD62E is a marker of intercellular communication associated with the development of SIR and suggests new mechanisms of RMP involvement in the reaction of organism to massive surgical injury.

Role of ADP-ribosyl cyclase in the pathogenesis of neurological disorders after coronary artery bypass surgery and experimental ischemia.

The pathogenesis of neuronal dysfunction was evaluated from the viewpoint of cellular disturbances in NAD(+) metabolism and changes in activity of NAD(+)-utilizing enzymes (e.g., ADP-ribosyl cyclase/CD38).

[Peripheral nerve block as a component of anesthesia during operations on lower extremity vessels].

Lumbar plexus block via inguinal paravascular access that was included as part of an anesthetic support at venectomy in the great saphenous vein, was studied for its impact on the development of postoperative pain syndrome and stress responses. The authors revealed a significant postoperative pain relief at rest and in motion, and reductions in the need for analgesics and in the magnitude of a stress response to a surgical injury.

[Comparative assessment of efficacy of tissue plasminogen activator and streptokinase in the treatment of patients with acute myocardial infarction].

Aim: To compare results of treatment of patients with acute myocardial infarction with tissue plasminogen activator (TPA) and streptokinase.

Material And Methods: TPA (100 mg intravenously) and streptokinase (1500000 U intravenously) were used for thrombolytic therapy of acute myocardial infarction in 114 and 118 patients, respectively.

Results: TPA treated compared with streptokinase treated patients were characterized by less frequent serious cardiac rhythm and conduction disturbances and hypotension during thrombolysis (p<0.

[The morphofunctional damage to the biomembranes in the lipid peroxidation syndrome in patients with the terminal stage of chronic kidney failure].

A total of 43 patients with a terminal stage of chronic renal failure (TCRF) who were on planned hemodialysis 8-12 hrs per week were studied for the status of lipid peroxidation, antioxidative system (AOS) as well as for the morphological and functional status of biological membranes. The study revealed high levels of lipid peroxidation featured by increased contents of malonic dialdehyde (MDA) and diene conjugates in the blood serum and red cells of the uremic patients. Besides, the functional incompetence of a nonenzymatic part of the AOS resulting in a decrease in the number of sulfhydryl groups in the red cells and alphatocopherol in the plasma was documented.