Transformational Leadership, Organizational Resilience, and Team Innovation Performance: A Model for Testing Moderation and Mediation Effects.

This study adopts transformational leadership as the research subject and aims to explore the effect of transformational leadership on organizational resilience and team innovation performance: to test the mediating role of organizational resilience between transformational leadership and team innovation performance, as well as to examine the moderating role that environmental uncertainty performs in the process of the mediation. By analyzing the data collected from a questionnaire, this research discovered that transformational leadership has a positive effect on team innovation performance, which is mediated by organizational resilience. This relationship is more significant when environmental uncertainty is considered as a moderator in the mediation process.

Construction of a Multi-View Deep Learning Model for the Severity Classification of Acute Pancreatitis.

Background: Acute pancreatitis (AP) is a prevalent pathological condition of abdomen characterized by sudden onset, high incidence and complex progression. Timely assessment of AP severity is crucial for informing intervention decisions so as to delay deterioration and reduce mortality rates. Existing AP-related scoring systems can only assess current condition of patients and utilize only a single type of clinical data, which is of great limitation.

HBx Facilitates Drug Resistance in Hepatocellular Carcinoma via CD133-regulated Self-renewal of Liver Cancer Stem Cells.

Background And Aims: Hepatitis B virus (HBV) infection contributes to hepatocellular carcinoma (HCC) tumorigenesis, drug resistance, and recurrence, although the underlying molecular mechanisms remain unclear. Recent studies suggest that HBV infection may be associated with liver cancer stem cells (LCSCs), but the exact mechanisms are yet to be resolved. In this study, we aimed to analyze the role of HBV infection in regulating the stemness of HCCs, which is closely linked to drug resistance.

Bioelectrically Reprogramming Hydrogels Rejuvenate Vascularized Bone Regeneration in Senescence.

Senescent bone tissue displays a pathological imbalance characterized by decreased angiogenesis, disrupted bioelectric signaling, ion dysregulation, and reduced stem cell differentiation. Once bone defects occur, this pathological imbalance makes them difficult to repair. An innovative synergistic therapeutic strategy is utilized to reverse these pathological imbalances via a conductive hydrogel doped with magnesium ion (Mg)-modified black phosphorus (BP).

Longitudinal monitoring of sewershed resistomes in socioeconomically diverse urban neighborhoods.

Background: Understanding factors associated with antimicrobial resistance (AMR) distribution across populations is a necessary step in planning mitigation measures. While associations between AMR and socioeconomic-status (SES), including employment and education have been increasingly recognized in low- and middle-income settings, connections are less clear in high-income countries where SES remains an important influence on other health outcomes.

Methods: We explored the relationship between SES and AMR in Calgary, Canada using spatially-resolved wastewater-based surveillance of resistomes detected by metagenomics across eight socio-economically diverse urban neighborhoods.