The Psychometric Performance of the Kansas City Cardiomyopathy Questionnaire-12 in Symptomatic Obstructive Hypertrophic Cardiomyopathy.

Background: A primary goal of treating patients with obstructive hypertrophic cardiomyopathy (oHCM) is to improve their symptoms, function and quality of life. Although the psychometric properties of the 23-item Kansas City Cardiomyopathy Questionnaire (KCCQ-23) have been described in oHCM, they have not been assessed for the shorter 12-item version (KCCQ-12), which is used increasingly in clinical practice.

Methods And Results: Using data from the EXPLORER-HCM trial, the psychometric properties of the KCCQ-12 were evaluated.

The Kansas City Cardiomyopathy Questionnaire in Relation to New York Heart Association Class.

Background: In order to identify candidacy and treatment response for patients with obstructive hypertrophic cardiomyopathy (oHCM), clinicians need an accurate means of assessing symptoms, function, and quality of life. While the New York Heart Association (NYHA) Classification is most often used for this purpose, the Kansas City Cardiomyopathy Questionnaire (KCCQ-23) is more accurate and sensitive to change, although less familiar to practicing clinicians. To support interpreting the KCCQ-23, we describe cross-sectional and longitudinal changes in KCCQ scores in the context of the NYHA.

Association of Tafamidis With Health Status in Patients With ATTR Cardiac Amyloidosis: A Post Hoc Analysis of the ATTR-ACT Randomized Clinical Trial.

Importance: Tafamidis reduced all-cause mortality and cardiovascular-related hospitalizations and minimized patient-reported health status deterioration at 30 months in patients with transthyretin (ATTR) amyloidosis. However, the clinical significance of health status changes remains unclear, particularly in patients with New York Heart Association (NYHA) class III symptoms who experienced more cardiovascular-related hospitalizations than those with NYHA class I-II symptoms.

Objective: To evaluate the health status of patients taking tafamidis with baseline NYHA class III symptoms.

The challenges inherent with anchor-based approaches to the interpretation of important change in clinical outcome assessments.

Purpose: Anchor-based methods are group-level approaches used to derive clinical outcome assessment (COA) interpretation thresholds of meaningful within-patient change over time for understanding impacts of disease and treatment. The methods explore the associations between change in the targeted concept of the COA measure and the concept measured by the external anchor(s), typically a global rating, chosen as easier to interpret than the COA measure. While they are valued for providing plausible interpretation thresholds, group-level anchor-based methods pose a number of inherent theoretical and methodological conundrums for interpreting individual-level change.