Impact of Social Disadvantage on Medical and Functional Severity in Children With Cerebral Palsy.

Background: Those with neurological disorders like cerebral palsy (CP) may experience an altered impact of social determinates of health on child functioning and well-being. We investigated the relationship between relative social advantage and medical and functional outcomes in a large cohort of children, adolescents and young adults with CP (n = 1269, aged 2-84 years).

Methods: We extracted data from the Cerebral Palsy Research Registry and dichotomized a range of independent factors (income, ethnicity and race) into advantaged and disadvantaged/vulnerable and a range of medical and functional outcomes (gross motor, manual ability, behaviour, breathing, nutritional intake, hearing, seizures, language and vision) and computed odds ratios using logistic regression.

Mapping management intensity types in grasslands with synergistic use of Sentinel-1 and Sentinel-2 satellite images.

Grasslands, being vital ecosystems with significant ecological and socio-economic importance, have been the subject of increasing attention due to their role in biodiversity conservation, carbon sequestration, and agricultural productivity. However, accurately classifying grassland management intensity, namely extensive and intensive practices, remains challenging, especially across large spatial extents. This research article presents a comprehensive investigation into the classification of grassland management intensity in two distinct regions of Poland, NUTS2 - namely Podlaskie (PL84) and Wielkopolskie (PL41), by integrating data from Sentinel-1 and Sentinel-2 satellite imagery.

Integrating AlphaFold pLDDT Scores into CABS-flex for enhanced protein flexibility simulations.

CABS-flex is a well-established method for fast protein flexibility simulations, offering an effective balance between computational efficiency and accuracy in modeling protein dynamics. To further enhance its predictive capabilities, we propose incorporating AlphaFold's predicted Local Distance Difference Test (pLDDT) scores into CABS-flex simulations. The pLDDT scores, which reflect the confidence of AlphaFold's structural predictions, were integrated with secondary structure information to refine the restraint schemes used in the simulations.

Renal resistive index assessment by intraoperative transesophageal echocardiography is associated with acute kidney injury after cardiac surgery: a prospective observational study.

Background: Acute kidney injury (AKI) is a major health burden after cardiac surgery. Renal vasoconstriction and venous congestion can be assessed via transesophageal echocardiography (TEE). The primary objective is to determine feasibility of measuring intraoperative Renal resistive index (RRI) and portal vein pulsatility fraction (PF) by TEE.

Considerations for Severe Acute Respiratory Syndrome Coronavirus 2 Genomic Surveillance: A Joint Consensus Recommendation of the Association for Molecular Pathology and Association of Public Health Laboratories.

Next-generation sequencing (NGS) has applications in research, epidemiology, oncology, and infectious disease diagnostics. Wide variability exists in NGS wet laboratory techniques and dry laboratory analytical considerations. Thus, many questions remain unanswered when NGS methods are implemented in laboratories for infectious disease testing.