Publications by authors named "K Wolk"
Hidradenitis suppurativa is a chronic inflammatory disease characterised by painful, deep-seated nodules, abscesses, and draining tunnels in the skin of axillary, inguinal, genitoanal, or inframammary areas. In recent years, the body of knowledge in hidradenitis suppurativa has advanced greatly. This disorder typically starts in the second or third decade of life.
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- - Palmoplantar pustulosis (PPP) is a painful chronic skin disorder affecting the palms and soles, with no approved treatments in Europe and the USA, although guselkumab is approved in Japan.
- - A phase II study involving 50 Caucasian patients showed that administering 100 mg of guselkumab subcutaneously for 24 weeks significantly reduced the severity of PPP, with a median improvement of 59.6% in the PPP severity index.
- - The study concluded that guselkumab could be a viable treatment option for Caucasian patients suffering from moderate-to-severe PPP, as indicated by substantial improvements in both clinical and quality of life measures.
Importance: Psoriasis is a chronic inflammatory skin disease with unmet needs for tailored treatment and therapy de-escalation strategies.
Objective: To evaluate early intervention with and prolonging the dosing interval for guselkumab, a p19 subunit-targeted interleukin (IL)-23 inhibitor, in patients with moderate to severe psoriasis.
Design, Setting, And Participants: The GUIDE clinical trial is an ongoing phase 3b, randomized, double-blinded trial conducted across 80 centers in Germany and France comprising 3 parts evaluating the impact of early disease intervention, prolonged dosing interval, and maintenance of response following treatment withdrawal among adults with moderate to severe plaque psoriasis.