Publications by authors named "K Wistuba-Hamprecht"
Article Synopsis
- Human gammadelta (γδ) T cells are present in healthy tissues and solid tumors, showing potential for strong anti-tumor effects, though results can vary across different cancer types.
- The infiltration patterns of γδ T cells in the tumor microenvironment (TME) are crucial for understanding their complex interactions with tumors.
- Various γδ T cell subsets can have both cytotoxic functions and immune-regulating roles, but their effectiveness can be hindered by factors in the TME, prompting ongoing research into their therapeutic use in cancer treatment.
Article Synopsis
- Mammalian innate-like T cells (ILTCs), such as MAIT, NKT, and γδ T cells, play key roles in liver inflammation, tissue repair, and maintaining immune balance.
- The review discusses how different ILTC subsets contribute to liver diseases, focusing on their pro- and anti-inflammatory actions based on specific contexts.
- Recent findings emphasize the interactions between ILTCs and other immune cells, suggesting potential immunomodulatory strategies for better outcomes in liver disease treatment.
Article Synopsis
- - Elevated levels of neutrophils in both blood and tumor tissue of advanced melanoma patients are linked to worse treatment responses and increased therapy resistance.
- - Analysis of patient serum samples and isolated neutrophils showed that neutrophils from melanoma patients had distinct functional characteristics and lower CD16 expression compared to healthy individuals.
- - Neutrophils were found to protect melanoma cells from apoptosis during targeted therapy, suggesting that their protease activity may play a significant role in promoting tumor survival against treatment.
Article Synopsis
- - This study introduces a new high-dimensional technique to analyze human γδ T cell subsets in their natural tissue settings, overcoming previous challenges related to antibody availability and technology limitations.
- - Researchers utilized a combination of multiplexed imaging and bioinformatics to identify and characterize γδ T cells in colon and colorectal cancer samples, uncovering various microenvironments and their interactions with both immune and cancer cells.
- - Although this initial study shows the promise of this advanced technology for exploring T cell diversity and microenvironments, further research is needed to connect specific T cell characteristics and microenvironment features with important clinical factors.
Background: Human cytomegalovirus (HCMV) can reactivate in the mammary gland during lactation and is shed into breast milk of nearly every HCMV-IgG-seropositive mother of a preterm infant. Dynamics of breast milk leukocytes during lactation, as well as blood leukocytes and the comparison between both in the context of HCMV reactivation is not well understood.
Methods: Here, we present the BlooMil study that aimed at comparing changes of immune cells in blood and breast milk from HCMV-seropositive- vs -seronegative mothers, collected at four time ranges up to two months post-partum.