Serum testosterone level correlates with left ventricular hypertrophy in older women.

Introduction: Sex hormones may play an important role in age-related cardiac remodeling. However, their impact on cardiac structure and function in females of advanced age still remains unclear. The aim of this study is to evaluate the relationship between sex hormones level and echocardiographic parameters in older women with concomitant cardiovascular diseases.

Hormones and depression in the advanced age.

Introduction: In older people, depression and mental disability are more frequently present than in younger subjects. It is found that depressionis a risk factor for dementia, just as dementia is a risk factor for depression. In turn, both disturbances are known to be influenced by hormones.

Gonadotropins at Advanced Age - Perhaps They Are Not So Bad? Correlations Between Gonadotropins and Sarcopenia Indicators in Older Adults.

Many hormones fluctuate during the aging process. It has been suggested that gonadotropins, which increase with age, contribute to the occurrence of many diseases and syndromes in older life, such as cardiovascular diseases, obesity, frailty syndrome and osteoporosis. This study aims to assess the relationship between circulating gonadotropins and other hormones potentially contributing to age-related functional decline and sarcopenia indicators in 39 male and 61 female community-dwelling seniors, mean age 80 years.

Endocrine and metabolic aspects of COVID-19.

The paper presents the theoretical considerations on the role of endocrine and metabolic alterations accompanying COVID-19 infection. These alterations may be presumed on the basis of the following two observations. Firstly, the virus SARS-CoV-2 responsible for the COVID-19 infection uses an important renin-angiotensin system (RAS) element - angiotensin-converting enzyme 2 (ACE2) - as a receptor protein for entry into target cells and, in consequence, disturbs the function of the main (circulating) renin-angiotensin-aldosterone system (RAAS) and of the local renin-angiotensin system localized in different tissues and organs.

Possible role of gonadotropin excess in age-related diseases - return to the old hypothesis in the light of current data.

The paper presents the evaluation of a hypothesis assuming that the elevated levels of gonadotropins which occur physiologically in older persons are involved by their direct extra-gonadal action in the pathogenesis of age-related disorders. The data on the possibilities of the direct action of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and their possible deleterious effects in the brain, bone, cardiovascular system and cancer in older persons are reviewed. A proposal of a new approach to the hormonal prevention treatment of age-related disorders (suppression of gonadotropins by means of gonadotropin releasing hormone analogs) is discussed.