Publications by authors named "K Wille"
While renal replacement therapy (RRT) allows for precise fluid management as well as addressing electrolyte imbalances and the removal of other necessary compounds, its early initiation has not shown benefit in the general critically ill population. Moreover, the effects of early RRT initiation specifically in patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) also remain unclear. This retrospective study investigated adult patients who underwent VA-ECMO between April 2018 and March 2022 and used the clone-censor-weight method to emulate a hypothetical target trial and compare two groups: patients who initiated RRT within 2 days of VA-ECMO initiation (Early) and those who did not (Late).
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- Glofitamab, a bispecific antibody targeting CD20 and CD3, shows promise for treating relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL) in heavily pretreated patients, with an overall response rate of 47%.
- In a study involving 70 patients in Germany, Austria, and Switzerland, the median number of prior treatments was four, with notable safety concerns including cytokine release syndrome in 40% of cases.
- Important findings indicate that elevated LDH levels predict poorer outcomes, and recent treatment with bendamustine may reduce the efficacy of glofitamab, suggesting careful treatment sequencing is essential.
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- The study investigates the effectiveness of high-resolution nerve ultrasound (HRUS) in diagnosing polyneuropathy caused by the chemotherapy drug vincristine.
- Twelve patients undergoing vincristine treatment and twelve healthy controls participated, with measurements taken at various intervals, including nerve cross-sectional areas (CSAs), neuropathy scores, and nerve conduction studies.
- Results indicated that while overall CSA at nerve entrapment sites increased alongside clinical symptoms, HRUS did not show significant changes at individual nerve sites, highlighting that clinical exams are key for early detection of vincristine-induced polyneuropathy.
Analysis of diagnostic criteria for ECMO-associated pneumonia.
Infect Control Hosp Epidemiol
December 2024
Article Synopsis
- Ventilator-associated pneumonia (VAP) significantly impacts critically ill patients and contributes to high rates of illness.
- The existing criteria for diagnosing VAP do not apply to patients on extracorporeal membrane oxygenation (ECMO).
- This study analyzes the effectiveness of current VAP criteria for ECMO patients and evaluates a new proposed standard for diagnosing pneumonia in these individuals.
Introduction: Men are generally more susceptible to bacterial infections than women. Central venous catheters (CVCs), often used to administer systemic treatment in patients with cancer, are an important source of infection. However, little is known about sex-specific differences of CVC-related bloodstream infections (CRBSIs) in patients with cancer.
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