Publications by authors named "K Wierzbicki"
The balance between apoptosis and autophagy plays a key role in cancer biology and treatment strategies. The aim of this study was to assess the effect of the mTOR kinase inhibitor everolimus and chloroquine on the regulation of proliferation, caspase-3 activation, and apoptosis in melanoma cells. We studied the activity of caspase-3 and the levels of caspase-3 and -9 using the Western blot technique.
View Article and Find Full Text PDFBackground: Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with limited treatment options. Although there have been recent advancements revealing genomic drivers of these tumors, it remains unclear which genomic signatures are associated with recurrence, particularly following R0 resection.
Methods: Adrenocortical carcinoma patients treated with adrenalectomy in the Cancer Genome Atlas with recurrence data were identified using cBioPortal.
Article Synopsis
- Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system, leading to inflammation and damage to nerve cells.
- A study measured the levels of specific chemokines in the cerebrospinal fluid of newly diagnosed MS patients and compared them to healthy individuals, finding significant differences in some chemokine levels.
- The results suggest that certain chemokines could be influencing inflammation early in the disease, indicating they might be important targets for future MS treatments.
(1) Background: Studies indicate that vitamin D (VitD) may reduce inflammation in multiple sclerosis (MS). The aim of the study was to assess the effect of supplementation with different doses of VitD on inflammation in relapsing-remitting MS (RRMS) patients. (2) Methods: The effect of 6-month supplementation with different doses of oral VitD (2000 IU/day) in a high-dose group (HD, = 23) and a low-dose group (15,960 IU/month) (LD, = 29) on selected markers of inflammation was assessed in 52 RRMS patients.
View Article and Find Full Text PDF