A Practical Guide to Assessing and Addressing Context in Quality Improvement.

This article highlights the often underestimated influence of context in improving the quality of inpatient pediatric care. Context includes environmental, social, cultural, and systemic factors that surround and influence health care service delivery and intervention outcomes. Underappreciation for context can be responsible for the lack of intervention success in improving patient outcomes and can lead to differences in outcomes when initiatives are replicated or spread across health care settings.

Mapping Hsp104 interactions using cross-linking mass spectrometry.

Molecular machines from the AAA+ (ATPases Associated with diverse cellular Activity) superfamily of protein disaggregases play important roles in protein folding, disaggregation and DNA processing. Recent cryo-EM structures of AAA+ molecular machines have uncovered nuanced changes in their conformation that underlie their specialized functions. Structural knowledge of these molecular machines in complex with substrates begins to explain their mechanism of activity.

Prevalence of Serious Bacterial Infection in Young Infants with Hypothermia with Positive Respiratory Pathogen Testing.

Objectives: We sought to compare the prevalence of serious bacterial infections (SBI; urinary tract infection, bacteremia, and/or meningitis) and invasive bacterial infections (IBI; bacteremia and/or meningitis) among infants with hypothermia with positive vs negative respiratory pathogen testing.

Study Design: We conducted a multicenter retrospective cohort study of infants ≤90 days presenting to an emergency department or directly admitted to a hospital from September 1, 2016, to May 5, 2021, with reported or documented hypothermia (≤36°C). Positive respiratory pathogen testing included positive single or multiplex nucleic acid amplification testing.