Publications by authors named "K Westerterp"
Nutritional epidemiology aims to link dietary exposures to chronic disease, but the instruments for evaluating dietary intake are inaccurate. One way to identify unreliable data and the sources of errors is to compare estimated intakes with the total energy expenditure (TEE). In this study, we used the International Atomic Energy Agency Doubly Labeled Water Database to derive a predictive equation for TEE using 6,497 measures of TEE in individuals aged 4 to 96 years.
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- Hypocretin deficiency leads to type 1 narcolepsy, which is associated with excessive daytime sleepiness and a high prevalence of overweight and obesity in patients.
- A study compared energy expenditure in ten males with narcolepsy to nine healthy controls using respiration chamber calorimetry and doubly labelled water.
- Results showed no significant differences in energy expenditure or physical activity between the two groups, suggesting that weight gain in narcolepsy might be influenced by factors other than metabolism, such as dietary habits.
Article Synopsis
- Doubly labeled water is the most reliable method for measuring total energy expenditure (TEE), but its accuracy can be affected by the isotope dilution space ratio (DSR).
- This study explored factors like age, sex, ethnicity, body composition, and geographical elevation to see how they influence DSR, using various statistical analysis methods.
- Results showed that while DSR decreased with age in individuals 60 and older, no significant effects were found from other variables, suggesting that previous estimates of TEE might be overestimating values for older individuals, especially those around 90 years old.
Adults with severe cerebral palsy (CP) are susceptible to malnutrition and metabolic disorders due to limited daily physical activity and challenges related to eating. We hypothesized that the condition of being underweight arises from inadequate energy intake due to difficulties in eating, rather than heightened total energy expenditure or an elevated resting metabolic rate. The present study encompassed 17 adults with severe CP (classified as GMFSC III-V).
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