Publications by authors named "K Welsh-Bohmer"
Article Synopsis
- Alzheimer's disease is a condition marked by cognitive and functional declines, and the study examined the effects of tilavonemab on these declines using the Clinical Dementia Rating (CDR) scale.
- Researchers used longitudinal Item Response Theory (IRT) models to analyze changes in early-stage AD patients, finding that cognitive decline was faster than functional decline, and tilavonemab did not provide significant benefits.
- The study highlighted a significant relationship between baseline severities and their progression rates, indicating that cognitive and functional declines in AD are interconnected, and suggested the usefulness of multidimensional IRT models for understanding disease progression.
Background And Objectives: Mild cognitive impairment (MCI) affects up to 22% of US older adults aged 65 and older. Research suggests that physicians may recommend less cardiovascular disease (CVD) treatment for older adults with MCI due to assumptions about their preferences. To delve into the disparity between patient preferences and physician assumptions in CVD treatment recommendations, we conducted a multi-site qualitative study to explore the underlying reasons for this discrepancy, providing insights into potential communication barriers and strategies to enhance patient-physician relationships.
View Article and Find Full Text PDFBackground: Anesthesia and/or surgery accelerate Alzheimer's disease pathology and cause memory deficits in animal models, yet there is a lack of prospective data comparing cerebrospinal fluid (CSF) Alzheimer's disease-related biomarker and cognitive trajectories in older adults who underwent surgery versus those who have not. Thus, the objective here was to better understand whether anesthesia and/or surgery contribute to cognitive decline or an acceleration of Alzheimer's disease-related pathology in older adults.
Methods: The authors enrolled 140 patients 60 yr or older undergoing major nonneurologic surgery and 51 nonsurgical controls via strata-based matching on age, sex, and years of education.
Objective: Examine the association between neuropsychologically assessed executive function and clinically identifiable white matter burden from magnetic resonance imaging, using a visual rating system (Scheltens Rating System) applied to the Cache County Memory Study (CCMS) archival database.
Method: We used the Scheltens Ratings Scale to quantify white matter lesion burden in the CCMS sample and used this metric as a predictor of executive function. The sample included 60 individuals with dementia and 13 healthy controls.