Publications by authors named "K Webert"
Objectives: Evidence-based protocols for managing bleeding emergencies in patients with immune thrombocytopenia (ITP) are lacking. We conducted a systematic review of treatments for critical bleeding in patients with ITP.
Methods: We included all study designs and extracted data in aggregate or individually for patients who received one or more interventions and for whom any of the following outcomes were reported: platelet count response, bleeding, disability, or death.
Article Synopsis
- The study examines the limitations of the current WHO bleeding scale for evaluating bleeding in acute leukaemia patients, which doesn't adequately capture minor bleeds or the overall burden of bleeding.
- Through interviews with 19 healthcare providers (HCPs), the research identifies key features that should inform a new classification system for bleeding events in these patients.
- The findings categorize bleeding into three groups: clinically significant, potentially serious, and not significant, and propose the next steps include obtaining patient perspectives to improve the bleeding definition further.
Background And Objectives: Haemolysis can occur following intravenous immunoglobulin (IVIG) infusion. Haemovigilance data were analysed using a novel approach for including two control groups with no haemolysis to IVIG. Objectives included a summary of all reactions to IVIG, rate estimates and analysis of haemolytic reactions including risk factors.
View Article and Find Full Text PDFBackground: In August 2017, Canadian Blood Services extended the shelf-life of platelet concentrates from 5 to 7 days. The clinical impacts of this policy change remain unclear.
Study Design And Methods: We used a before-after retrospective design of platelet-transfused adult inpatients in Hamilton, ON, Canada.
Background: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts and increased risk of bleeding. In preparation for an upcoming guideline, the ITP Emergency Management Guideline Panel, including clinical experts in hematology, emergency medicine, research methodology, and patient representatives, identified the need for a standardized definition of a critical ITP bleed. The goal of the definition was to distinguish critical bleeds from bleeds that may not require urgent treatment, typically in the context of severe thrombocytopenia.
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