Auditory evoked potentials in multiple sclerosis: alpha responses are reduced in amplitude, but theta responses are not altered.

Auditory evoked potentials (EPs) were measured in a group of 16 multiple sclerosis (MS) patients and in a control group of 20 subjects. In vertex recordings, response amplitudes were reduced in the MS group. Remarkably, EP frequency components computed from the averaged EPs showed different degrees of amplitude reduction in different frequency channels: alpha (7-12 Hz) components were reduced whereas theta (4-7 Hz) responses were not altered.

Visual evoked potentials in multiple sclerosis: frequency response shows reduced alpha amplitude.

Visual evoked potentials were measured in a group of 16 multiple sclerosis (MS) patients and in a control group of 20 subjects. With respect to vertex and occipital recordings, latencies of main peaks were prolonged and response amplitudes were reduced in the MS group. As a result of frequency domain analysis we found that the amplitude reduction was not uniform in all frequency ranges: alpha (7-12 (Hz) components of EPs were markedly reduced whereas theta (4-7 Hz) responses were not altered.

[Oligoclonal bands of four IgG subfractions and IgM and IgA in the serum and cerebrospinal fluid of friends with multiple sclerosis].

Using the methods of isoelectric focusing and immunoblotting the CSF and serum immunoglobulins were analysed in 47 patients with multiple sclerosis and 57 patients with other neurological diseases. The oligoclonal bands were found in the IgG fraction in 42 multiple sclerosis (ms) patients and 13 controls. The percent proportion of oligoclonal bands in various IgG subfractions was similar in both groups and was: 66% and 61% respectively for IgG1, 22% and 22% for IgG3, 12% and 17% for IgG2.

[Cerebrospinal fluid parameters in Guillain-Barré polyradiculitis. Importance of barrier disorder and intrathecal immunoglobulin synthesis].

With routine CSF determination of 21 patients with GBS the BBB and the intrathecal IgG synthesis was investigated when calculated CSF/serum albumin ratio and CSF IgG-index respectively. Only in 2 of 21 patients (9.5%) an intrathecal IgG synthesis and in 14 of 21 patients (67%) a BBB damage was found.

Expression of alpha 2-glycoprotein by glial precursor cells: an immunocytochemical study with glial cultures.

Studies on the presence of the brain-specific alpha 2-glycoprotein in cultures of newborn rat brain cells revealed that a population of glial precursor cells expressed this antigen at an early stage of development. This cell population consisted of small, phase-dark cells that proliferated in culture and occupied the surface of a layer of flat epithelial-like astrocytes. The latter cell type did not react with the antibodies.