Publications by authors named "K Walia"
Article Synopsis
- Pseudomonas aeruginosa is highly resistant to antibiotics due to intrinsic and acquired mechanisms, primarily utilizing Pseudomonas-derived cephalosporinase (PDC) and serine Ambler class C β-lactamases through the AmpC gene system.
- * A study analyzed 111 P. aeruginosa isolates from India, identifying the ESAC allele PDC-447 as the most prevalent variant, particularly among carbapenem-resistant strains, while also noting other significant variants like PDC-398 and PDC-397.
- * Genetic mutations in the PDC enzyme, such as T105A in the H-helix region, were linked to increased antibiotic resistance, emphasizing the complexity of resistance mechanisms and
Implementing a healthcare-associated bloodstream infection surveillance network in India: a mixed-methods study on the best practices, challenges and opportunities, 2022.
Antimicrob Resist Infect Control
December 2024
Background: Healthcare-associated bloodstream infections (BSI) threaten patient safety and are the third most common healthcare-associated infection (HAI) in low- and middle-income countries. An intensive-care-unit (ICU) based HAI surveillance network recording BSIs was started in India in 2017. We evaluated this surveillance network's ability to detect BSI to identify best practices, challenges, and opportunities in its implementation.
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- This study tested two new antibiotics, cefiderocol and cefepime/zidebactam, against NDM-producing Enterobacterales in India, aiming to address challenges posed by metallo-β-lactamases.
- Cefiderocol showed limited effectiveness, with variable susceptibility rates, while cefepime/zidebactam showed high susceptibility (≥90%) across the tested isolates.
- The research highlights the need for new treatment options for infections caused by carbapenem-resistant bacteria, particularly with the dominance of NDM in the region.