Development of topical thymoquinone loaded polymer-lipid hybrid vesicular gel: and evaluation.

Thymoquinone (TH), a naturally occurring moiety shows excellent anticancer properties and in the present study, TH loaded polymer hybrid lipid vesicles (TH PLH) were formulated, and cytotoxicity towards breast cancer cell lines (MCF-7 and MBD-MB 231 cells) was determined. TH PLH was primed by the ethanol spraying method and were characterized for various attributes like particle size, morphology, percentage drug entrapment, elasticity, rheological, zeta potential, etc. The prepared TH PLH Vesicles showed an average particle size from 344.

3D printing in pharmaceuticals: An emerging technology full of challenges.

Although in its infancy, when compared with the other sectors, year 2005 marked the rapid evolution of 3 Dimensional printing (3DP) technologies in pharma sector with a huge potential in the dosage form designing and personalisation of the medication. 3DP is an innovative and highly promising way for the instant manufacturing in contrast with the tailored made conventional manufacturing. Various 3DP technologies are categorized into the various areas on the basis of the type of material used, deposition techniques and the solidification/fusion techniques.

Influence of electrical field during crystallization on dielectric constant, zeta potential and oxidation and reduction properties of paracetamol.

The crystals of paracetamol obtained by exposure of its saturation solution to DC electric field of varying duration (1-6 min) supplied by means of silver electrodes (the term coined as ENS-crystals). These ENS-crystals were analyzed for electrical properties such as dielectric constant, zeta potential, electrochemical properties such as oxidation and reduction potential (EP), current (iP), and charges (Ah) means of cyclic voltammetry. The dielectric constant is increased at 1 kHz and 100 kHz frequencies.

Evaluation of release retarding property of gum damar and gum copal in combination with hydroxypropyl methylcellulose.

The formulations consisting of a hydrophilic and hydrophobic material were investigated for effect on drug-release pattern from the matrices. Gum damar and gum copal being water-insoluble were used to study the efficiency of combined matrices to sustain the release of drug. Hydroxypropyl methylcellulose K100M and diclofenac sodium were used as the hydrophilic material and model drug, respectively.

Formulation and evaluation of a sustained-release tablets of metformin hydrochloride using hydrophilic synthetic and hydrophobic natural polymers.

Metformin hydrochloride has relatively short plasma half-life, low absolute bioavailability. The need for the administration two to three times a day when larger doses are required can decrease patient compliance. Sustained release formulation that would maintain plasma level for 8-12 h might be sufficient for daily dosing of metformin.