Publications by authors named "K W Wilhelmsen"
Neutrophils, particularly low-density neutrophils (LDNs), are believed to contribute to acute COVID-19 severity. Here, we showed that neutrophilia can be detected acutely and even months after SARS-CoV-2 infection in patients and mice, while neutrophil depletion reduced disease severity in mice. A key factor in neutrophilia and severe disease in infected mice was traced to the chemokine CXCL12 secreted by bone marrow cells and unexpectedly, endothelial cells.
View Article and Find Full Text PDFEarly-onset Alzheimer's disease (EOAD) is less investigated than the more common late-onset Alzheimer's disease (LOAD) despite its more aggressive course. A cortical signature of EOAD was recently proposed and may facilitate EOAD investigation. Here, we aimed to validate this proposed MRI biomarker of EOAD neurodegeneration in an Appalachian clinical cohort.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is classically characterized by alterations in memory consolidation. With the advent of diagnostic biomarkers, some patients clinically diagnosed with AD display biomarkers inconsistent with the diagnosis.
Objective: We aimed to explore differences in memory consolidation and neurodegeneration of the temporal and parietal lobes as a function of amyloid-β status in amnestic mild cognitive impairment (aMCI).
Article Synopsis
- Alcohol Use Disorder (AUD) shows varied symptoms, but past studies focused on genetic links without exploring the severity of these symptoms, which this study aims to address.
- Using a polygenic risk score (PRS) based on data from previous studies, researchers assessed how genetic factors relate to the severity of individual AUD symptoms and overall disorder severity.
- The findings revealed a strong correlation between genetic and phenotypic severity of AUD symptoms, but the PRS did not uniquely predict individual symptoms outside of overall AUD severity, suggesting a need for future research to examine symptoms individually for better understanding.
Executive function and cortical thickness in biomarker aMCI.
Appl Neuropsychol Adult
August 2024
Introduction: Memory deficits are the primary symptom in amnestic Mild Cognitive Impairment (aMCI); however, executive function (EF) deficits are common. The current study examined EF in aMCI based upon amyloid status (A+/A-) and regional atrophy in signature areas of Alzheimer's disease (AD).
Method: Participants included 110 individuals with aMCI (A+ = 66; A- = 44) and 33 cognitively healthy participants (HP).