Publications by authors named "K W Traxler"
Objectives: Mirikizumab demonstrated significant efficacy compared to placebo in patients with Crohn's disease (CD) in the phase 3 VIVID-1 study. Here, we report the impact of mirikizumab versus placebo on health-related quality of life (HRQoL) and work productivity in VIVID-1.
Methods: VIVID-1 patients randomized to receive mirikizumab (N=579) or placebo (N=199) were included.
Article Synopsis
- Mirikizumab, an anti-IL-23 antibody, showed significant effectiveness in improving quality of life (QoL) for patients with ulcerative colitis in phase 3 trials LUCENT-1 and LUCENT-2.
- In these studies, over 1600 patients were treated with either mirikizumab or a placebo, with QoL measured at various timelines using specific questionnaires.
- Results indicated that patients receiving mirikizumab experienced greater improvements in health-related quality of life metrics compared to those on placebo, demonstrating its efficacy in managing ulcerative colitis symptoms.
Article Synopsis
- The study aimed to assess changes in balance and mobility in chronic stroke patients after specific task-oriented training (TOT) with or without manual therapy (MT-TOT), and evaluate the feasibility of a larger randomized controlled trial (RCT).
- A pilot RCT involved 36 stroke patients divided into groups receiving MT-TOT, TOT, or no intervention, with outcomes measured in terms of balance, mobility, falls, and quality of life.
- Results showed that both MT-TOT and TOT were effective in improving various aspects of mobility and balance, indicating the potential for conducting a larger RCT to further validate these findings.
Background: Large studies have shown that stroke is among the most relevant causes of acquired adult disability. Walking and balance impairment in stroke survivors often contribute to a restriction in daily activities and social participation. Task-oriented training (TOT) is an effective treatment strategy and manual therapy (MT) is used successfully to enhance ankle joint flexibility in this population.
View Article and Find Full Text PDFTo evaluate a business-centered assignment implemented in a pharmacy elective course at two different institutions and analyze student perceptions of the delivery platforms used and the value and utility of the assignment. The ambulatory care electives at Butler University and Samford University introduce students to the expanding role of the ambulatory care pharmacist, emphasizing business plan development for new ambulatory care pharmacy services. As part of the elective, students are asked to work in groups to complete a business plan for a new ambulatory care service of their choosing.
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