Publications by authors named "K W Strauss"
Steroid-refractory acute and chronic graft-versus-host disease (SR-a/cGvHD) represents a potential life-threatening complication following allogeneic stem-cell transplantation (allo-SCT). The JAK1/2-inhibitor ruxolitinib and the extracorporeal photopheresis (ECP) have been shown to significantly improve the overall response rate (ORR) in this setting. However, about 30-40 % of high-risk patients do not respond to monotherapy and/or experience side effects.
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- * Results showed no deaths, significant discomfort, or severe device malfunctions post-MRI, with only two instances of minor atrial arrhythmia, both in patients with MR-conditional pacemakers.
- * The findings support that MRI can be safely conducted in patients with CIEDs without adverse effects or changes in device performance, following proper protocols and monitoring.
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- The study investigates the link between sports-related physical activity and heart issues in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), noting that there's a lack of standard guidelines for assessing activity levels.
- Researchers conducted a retrospective analysis of 124 ARVC patients, finding that higher levels of cumulative physical activity, particularly from sports, correlated with increased risks of heart failure and serious heart rhythm problems.
- The results suggest that continuous tracking of physical activity can help identify risk levels for ARVC patients, highlighting that while sports activity is a significant factor, non-sports-related activities did not show a strong correlation with worsening heart conditions.
Unlabelled: Alveolar bone supports and anchors teeth. The parathyroid hormone-related protein (PTHrP) pathway plays a key role in alveolar bone biology. Salt inducible kinases (SIKs) are important downstream regulators of PTH/PTHrP signaling in the appendicular skeleton where SIK inhibition increases bone formation and trabecular bone mass.
View Article and Find Full Text PDFPhase 3 randomized controlled trials (RCTs), while the gold standard for treatment efficacy and safety, are not always feasible, are expensive, can be prolonged and can be limited in generalizability. Other under-recognized sources of evidence can also help advance drug development. Basic science, proof-of-concept studies and early-phase RCTs can provide evidence regarding the potential for clinical benefit.
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