Publications by authors named "K W Singletary"
Article Synopsis
- Insomnia is common in individuals with Autism Spectrum Disorder (ASD), and recent studies indicate that sleep problems may be more severe in females with ASD compared to males.
- The study utilized a Shank3 mouse model to examine sex-specific sleep differences through polysomnography, focusing on baseline sleep patterns and responses to sleep deprivation.
- Results revealed distinct sleep behaviors between male and female Shank3 mice, with males showing less sleep during their active phase and females displaying altered sleep patterns, highlighting how sex and genetic factors can influence sleep in ASD.
Sleep deprivation (SD) has negative effects on brain and body function. Sleep problems are prevalent in a variety of disorders, including neurodevelopmental and psychiatric conditions. Thus, understanding the molecular consequences of SD is of fundamental importance in biology.
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- Sleep regulates a biological function that's crucial for recovery, increasing the need for sleep after wakefulness, especially following acute sleep deprivation (SD).
- Research on mice shows that 5-6 hours of SD significantly alters gene expression, with about half of the cortical genes affected, primarily downregulated.
- After 2 hours of recovery sleep (RS), most of the altered gene expression normalizes, linking recovery to processes like metabolism and DNA repair, while some changes related to stress and cholesterol metabolism take longer to adjust and suggest broader effects beyond just sleep.
Sleep deprivation (SD) has negative effects on brain function. Sleep problems are prevalent in neurodevelopmental, neurodegenerative and psychiatric disorders. Thus, understanding the molecular consequences of SD is of fundamental importance in neuroscience.
View Article and Find Full Text PDFSleep deprivation (SD) results in profound cellular and molecular changes in the adult mammalian brain. Some of these changes may result in, or aggravate, brain disease. However, little is known about how SD impacts gene expression in developing animals.
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