Publications by authors named "K W Moles"
Characterizing the mechanisms influencing the distribution of genetic variation in aquatic species can be difficult due to the dynamic nature of hydrological landscapes. In North America's Central Highlands, a complex history of glacial dynamics, long-term isolation, and secondary contact have shaped genetic variation in aquatic species. Although the effects of glacial history have been demonstrated in many taxa, responses are often lineage- or species-specific and driven by organismal ecology.
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- Recent studies highlight that both excessive and insufficient nitric oxide (NO) production play key roles in heart failure with preserved ejection fraction (HFpEF), raising interest in NO-targeted therapies.
- A mouse model (using high-fat diets and specific treatments) was used to explore the effects of a dual-nitric oxide therapy (sodium nitrite and hydralazine) on heart function and stress levels related to HFpEF.
- The treatment notably improved NO availability and heart function, reduced oxidative stress, and enhanced exercise capacity, suggesting it may effectively mitigate the severity of HFpEF.
Background Hydrogen sulfide (HS) is an important endogenous physiological signaling molecule and exerts protective properties in the cardiovascular system. Cystathionine γ-lyase (CSE), 1 of 3 HS producing enzyme, is predominantly localized in the vascular endothelium. However, the regulation of CSE in vascular endothelium remains incompletely understood.
View Article and Find Full Text PDFObjective: To test the hypothesis that chromosomal microarray analysis frequently diagnoses conditions that require specific medical follow-up and that referring physicians respond appropriately to abnormal test results.
Methods: A total of 46,298 postnatal patients were tested by chromosomal microarray analysis for a variety of indications, most commonly intellectual disability/developmental delay, congenital anomalies, dysmorphic features, and neurobehavioral problems. The frequency of detection of abnormalities associated with actionable clinical features was tallied, and the rate of physician response to a subset of abnormal tests results was monitored.
Purpose: To investigate the effects of four office chairs on the postural angles of the lumbopelvic and cervical regions.
Research Question: Which chair(s) produce an "ideal" spinal posture?
Methods: An experimental same subject design was used involving healthy subjects (n = 14) who conducted a typing task whilst sitting on four different office chairs; two "dynamic" chairs (Vari-Kneeler and Swopper), and two static chairs (Saddle and Standard Office with back removed). Data collection was via digital photogrammetry, measuring pelvic and lumbar angles, neck angle and head tilt which were then analysed within MatLab.