Publications by authors named "K W Ivens"
Article Synopsis
- Vaccination is crucial for kidney transplant recipients (KTRs) against SARS-CoV-2, but their immune response is often weaker than that of healthy individuals.
- The study analyzed the T-cell response in 148 KTRs, finding lower spike-specific T cell frequencies compared to controls, but a positive association was seen with spike-specific antibodies and certain vaccination strategies.
- KTRs who contracted SARS-CoV-2 post-vaccination exhibited significantly enhanced T-cell responses, indicating that hybrid immunity (from both vaccination and infection) provides stronger protection.
Article Synopsis
- A study examined how modifying vaccination strategies, specifically by reducing mycophenolate mofetil (MMF) doses, can enhance the immune response in kidney transplant recipients (KTRs) post-SARS-CoV-2 vaccination.
- Out of 174 previously seronegative KTRs, 32% became seropositive after a third vaccination, but only three developed neutralizing antibodies against the omicron variant.
- The findings suggest that a reduction of MMF by at least 33% prior to vaccination can significantly improve seroconversion rates in KTRs, potentially improving the effectiveness of the vaccine.
Background: Patients with kidney failure on dialysis or after renal transplantation have a high risk for severe COVID-19 infection, and vaccination against SARS-CoV-2 is the only expedient prophylaxis. Generally, immune responses are attenuated in patients with kidney failure, however, systematic analyses of immune responses to SARS-CoV-2 vaccination in patients on dialysis and in kidney transplant recipients (KTRs) are still needed.
Methods: In this prospective, multicentric cohort study, antibody responses to COVID-19 mRNA vaccines (BNT162b2 [BioNTech/Pfizer] or mRNA-1273 [Moderna]) were measured in 32 patients on dialysis and in 28 KTRs.
Cross-Reactivity of Chili Peppers ( sp.) with the xMAP Food Allergen Detection Assay.
J Agric Food Chem
November 2021
The xMAP food allergen detection assay (xMAP FADA) is an advanced multiplex immunoassay with multiple antibodies for each of 15 target food allergens and gluten, allowing for signal confirmation and antigenic profiling to occur in a single analysis. Botanicals used as spices are complex matrices for allergen analysis because they can exhibit inherent cross-reactivity with antibodies employed by the assays. Preliminary examinations of botanicals revealed chili peppers to have notably high levels of cross-reactivity with Brazil nut and hazelnut antibody bead sets in the xMAP FADA.
View Article and Find Full Text PDFKidney transplant recipients (KTRs) are extremely vulnerable to SARS-CoV-2 infection and show an impaired immune response to SARS-CoV-2 vaccination. We analyzed factors related to vaccination efficiency in KTRs. In a multicenter prospective observational study (NCT04743947), IgG antibodies levels against SARS-CoV-2 spike S1 subunit and their neutralization capacity after SARS-CoV-2 vaccination were analyzed in 225 KTRs and compared to 176 controls.
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