3D bioprinting meniscus tissue onboard the International Space Station.

We bioprinted meniscus tissue on the International Space Station (ISS) using the onboard BioFabrication Facility (BFF). The three dimensional (3D) printing bioink, cells, culture media and fixative were delivered to the ISS on NG-18 and SpX-27 vehicles and stored prior to the printing operation. The meniscus tissue was fabricated from ink composed of collagens type I and II, chondroitin sulfate and mesenchymal stem cells.

An Exosome-Laden Hydrogel Wound Dressing That Can Be Point-of-Need Manufactured in Austere and Operational Environments.

Skin wounds often form scar tissue during healing. Early intervention with tissue-engineered materials and cell therapies may promote scar-free healing. Exosomes and extracellular vesicles (EV) secreted by mesenchymal stromal cells (MSC) are believed to have high regenerative capacity.

Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use.

The webinar series and workshop titled “Trust Your Gut: Establishing Confidence in Gastrointestinal Models – An Overview of the State of the Science and Contexts of Use” was co-organized by NICEATM, NIEHS, FDA, EPA, CPSC, DoD, and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT) and hosted at the National Institutes of Health in Bethesda, MD, USA on October 11-12, 2023. New approach methods (NAMs) for assessing issues of gastrointestinal tract (GIT)- related toxicity offer promise in addressing some of the limitations associated with animal-based assessments. GIT NAMs vary in complexity, from two-dimensional monolayer cell line-based systems to sophisticated 3-dimensional organoid systems derived from human primary cells.

Point-of-Need Additive Manufacturing in Austere Arctic Environments: An Evaluation of Medical Logistics Requirements and Capabilities Demonstration.

Medical response to military conflicts, natural disasters, and humanitarian crises are challenged by operational logistics with unreliable supply chains, delayed medical evacuation, and compatibility of the disparate medical equipment and consumables. In these environments, stocks of supplies will become more quickly depleted and the need for equipment parts increases secondary to their higher likelihood for failure from overuse. Additive Manufacturing (AM), or 3D printing, at or closer to the point-of-need provides potential solutions to mitigate these logistics challenges.

The Sussex COVID-19 Modelling Cell: the methods and successes of a collaboration between public health teams in local authorities, NHS hospital trusts, NHS commissioners, and universities.

Background: The Sussex Modelling Cell (SMC) is a consortium, formed during the COVID-19 pandemic, of representatives from NHS Sussex, and the local authorities and universities in Sussex. The SMC aimed to provide public health teams with local-data-driven modelling, data analysis, and policy and commissioning advice to mitigate the impact of the pandemic on the local population. It also aimed to answer operational questions, since the Government's forecasts were not suitably applicable.