Publications by authors named "K Vuori"
Article Synopsis
- * Aged individuals showed an increase in macrophages with a tolerogenic phenotype and dysfunctional CD8-positive T cells, while profibrotic macrophages were reduced.
- * Inhibiting TREM1 decreased melanoma growth in younger mice, whereas inhibiting TREM2 helped prevent lung metastasis in older mice, suggesting new treatment targets for age-related melanoma immunotherapy.
Article Synopsis
- * Researchers found that a fusion protein called SS18-SSX drives the cancer's growth, and by analyzing cancer data, they identified that SUMO2 is a key gene that SySa cells rely on to survive.
- * The drug TAK-981, which inhibits SUMO2, was shown to effectively stop SySa cell growth and reverse harmful gene activities tied to the cancer, suggesting it could be a promising targeted treatment option as it is already in clinical trials for other cancers.
Acute leukemia is a particularly problematic collection of hematological cancers, and, while somewhat rare, the survival rate of patients is typically abysmal without bone marrow transplantation. Furthermore, traditional chemotherapies used as standard-of-care for patients cause significant side effects. Understanding the evolution of leukemia to identify novel targets and, therefore, drug treatment regimens is a significant medical need.
View Article and Find Full Text PDFIntroduction: Otitis in dogs is often chronic while local treatment primarily consists of flushing, antibiotics, and/or antifungals. We were interested in finding early life variables that associate with otitis later in life, preferably some that could be modified.
Methods: A cross-sectional hypothesis-driven study with longitudinal data was performed to search for associations between pre- and postnatal exposures, and the incidence of owner-reported otitis in dogs at over 1 year of age.
Introduction: Epilepsy is a serious and common neurological condition in dogs, despite the wide number of antiepileptic drugs available, in approximately one third of the patients, epilepsy remains unsatisfactorily controlled. We aim to analyze whether feeding dietary fat sources during puppyhood was associated with canine epilepsy in adulthood.
Methods: A nested case-control study was compiled from the validated DogRisk food frequency questionnaire (DogRisk FFQ).