Frequency of rare BCR-ABL1 fusion transcripts in chronic myeloid leukemia patients.

Introduction: The hallmark of chronic myeloid leukemia (CML) is the presence of Philadelphia chromosome, its resultant fusion transcript (BCR-ABL1), and fusion protein (p210). Alternate breakpoints in BCR (m-bcr, μ-bcr, and others) or ABL1 result in the expression of few rare fusion transcripts (e19a2, e1a2, e13a3, e14a3) and fusion proteins (p190, p200, p225) whose exact clinical significance remains to be determined.

Methods: Our study was designed to determine the type and frequency of BCR-ABL1 fusion transcripts in 1260 CML patients and to analyze the prognosis and treatment response in patients harboring rare BCR-ABL1 fusion transcripts.

Extracorporeal shock wave therapy in periodontics: A new paradigm.

The quest for exploring new frontiers in the field of medical science for efficient and improved treatment modalities has always been on a rise. Extracorporeal shock wave therapy (ESWT) has been enormously used in medical practice, principally, for the management of urolithiasis, cholelithiasis and also in various orthopedic and musculoskeletal disorders. The efficacy of ESWT in the stimulation of osteoblasts, fibroblasts, induction of neovascularization and increased expression of bone morphogenic proteins has been well documented in the literature.

Polymorphism and overexpression of HER2/neu among ovarian carcinoma women from Tiruchirapalli, Tamil Nadu, India.

Purpose: Alteration and overexpression of HER2 proto-oncogene have been implicated in the carcinogenesis and prognosis of ovarian cancer. We evaluated this hypothesis among women with ovarian carcinoma patients from Tiruchirapalli, Tamil Nadu, India.

Methods: Genomic DNA was extracted from 72 case patients and 288 control subjects and was examined for I655V polymorphism by PCR-RFLP based assay.

Prevalence of high-risk HPV and associated risk factors in cases of cervical carcinoma in Tamil Nadu, India.

Objective: To assess the prevalence of HPV infection among women with cervical cancer in Tiruchirapalli, Tamil Nadu, India.

Methods: A case-control study was conducted with 246 women with cervical cancer and 257 control participants aged between 20 and 70 years. The presence of HPV DNA was determined using the MY09/11 PCR protocol, the GP5(+)/6(+) PCR protocol, and type-specific PCR-based assays.

Prevalence of human papillomavirus (HPV) among college going girls using self collected urine samples from Tiruchirappalli, Tamilnadu.

Purpose: The study aimed to identify the status of HPV infection among young sexually unexposed girls from Tiruchriapalli district, Tamilnadu, India.

Methods: The distribution of HPV genotypes was evaluated by PCR DNA genotyping after self sampling from 246 study subjects.

Results: Positivity for HPV DNA was reported among 9.