Effect of Hepatitis C Viremia on Posttransplant Diabetes Mellitus in Liver Transplant Recipients.

Introduction: Posttransplant diabetes mellitus (PTDM) can increase morbidity and mortality in liver transplant recipients. Although hepatitis C seropositivity is a known risk factor for PTDM, the impact of viremia versus no viremia at time of transplant is unknown.

Project Aims: This program evaluation sought to compare PTDM in hepatitis C seropositive patients with and without viremia at the time of liver transplant.

Invasive Colonic Mucormycosis in an Immunocompromised Postliver Transplant Patient.

Mucormycosis (zygomycosis) is an invasive fungal disease caused by species, most commonly implicated in diabetic ketoacidosis and other immunocompromised states. This report presents a unique case of colonic mucormycosis in a patient several weeks after liver transplant. The patient's course was complicated by polymicrobial infection and intra-abdominal abscesses, ultimately leading to septic shock and death.

An HCV-positive recipient of an HCV-positive donor liver successfully treated before and immediately after liver transplant with daclatasvir, sofosbuvir, and ribavirin.

This case suggests that initiation of HCV therapy immediately after liver transplantation with well-tolerated, all-oral regimens may achieve a virologic cure in HCV-positive recipients, thus preventing post-transplant HCV recurrence and associated disease progression. This strategy may broaden utilization of HCV-positive donor livers, potentially including HCV-negative transplant recipients.

Progression of morphological changes after transplantation of a liver with heterozygous α-1 antitrypsin deficiency.

Inadvertent transplantation of an α-1 antitrypsin-deficient liver into an adult man provided a unique opportunity to follow the natural history of morphological changes in serial liver biopsies. After doing well initially, the patient developed liver function test abnormalities 6 years posttransplant, but biopsies at that time and 2 years later revealed only chronic hepatitis with no specific features. It was only upon repeat biopsy 10 years posttransplant that characteristic cytoplasmic inclusions appeared.